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2′,4′,6′-Trihydroxyacetophenone monohydrate

Name: 2′,4′,6′-Trihydroxyacetophenone monohydrate
Brand: SIAL

matrix substance for MALDI-MS, ≥99.5%

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Synonym(s):

2-Acetylphloroglucinol, THAP

Linear Formula:

(HO)₃C₆H₂COCH₃·H₂O

CAS Number:

249278-28-2

Molecular Weight:

186.16

Beilstein:

9288656

MDL number:

MFCD00149091

PubChem Substance ID:

329770099

NACRES:

NA.21

grade

matrix substance for MALDI-MS

Quality Level

100

Assay

≥99.5% (HPLC)
≥99.5%

form

solid

analyte chemical class(es)

glycans, oligonucleotides, peptides, proteins

technique(s)

MALDI-MS: suitable

color

light yellow

mp

218-222 °C
219-221 °C (lit.)

cation traces

Ca: ≤200 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

suitability

in accordance for UV test

SMILES string

O.CC(=O)c1c(O)cc(O)cc1O

InChI

1S/C8H8O4.H2O/c1-4(9)8-6(11)2-5(10)3-7(8)12;/h2-3,10-12H,1H3;1H2

InChI key

GDSIBPPJKSBCMF-UHFFFAOYSA-N

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Chromatography & Spectroscopy Reagents

General description

MALDI-MS analyzes require highest purity matrices and reagents, as organic or trace metal contamination causes adverse effects during crystallization, ionization or measurement. Therefore, our portfolio of MALDI matrices and reagents such as 2′,4′,6′-Trihydroxyacetophenone monohydrate are designed to fulfill the demanding requirements of today′s challenging applications.

Application

2′,4′,6′-Trihydroxyacetophenone monohydrate has been used as a matrix for oligosaccharide and glycopeptide analysis using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI/TOF).

Used in MALDI analysis of acidic glycans and glycopeptides in negative ion mode. Lower limit of detection than 6-aza-2-thiothimidine.

related product

Product No.

Description

Pricing

Signal Word

Warning

Hazard Statements

H315 - H319 - H335

Precautionary Statements

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Analysis of acidic oligosaccharides and glycopeptides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Papac, Damon I., Anissa Wong, and Andrew JS Jones.

Analytical Chemistry, 68.18, 3215-3223 (1996)

Analysis of acidic oligosaccharides and glycopeptides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

D I Papac et al.

Analytical chemistry, 68(18), 3215-3223 (1996-09-15)

2,5-Dihydroxybenzoic acid (DHB) is the most commonly used matrix for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI/TOF) of oligosaccharides. Because acidic, sialylated oligosaccharides are detected at only the low picomole level with DHB, alternative matrices were screened to identify a

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a powerful tool for the mass and sequence analysis of natural and modified oligonucleotides.

U Pieles et al.

Nucleic acids research, 21(14), 3191-3196 (1993-07-11)

We report the analysis and characterization of natural and modified oligonucleotides by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). The present technology was highly improved for this class of compounds by using a new matrix, 2,4,6-trihydroxy acetophenone, together

A novel binary matrix consisting of graphene oxide and caffeic acid for the analysis of scutellarin and its metabolites in mouse kidney by MALDI imaging.

Tao Wang et al.

The Analyst, 146(1), 289-295 (2020-11-04)

Although the in vivo metabolic pathways of scutellarin, a traditional Chinese medicine, have been investigated via different liquid chromatography techniques, studies on the distribution and location of scutellarin within organ tissue sections have not been reported. Matrix-assisted laser desorption/ionization mass

Analysis of anthocyanins in red wine and fruit juice using MALDI-MS.

J Wang et al.

Journal of agricultural and food chemistry, 47(5), 2009-2015 (1999-12-20)

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is a powerful new technique that will have a great impact on food analysis. This study is the first to demonstrate the applicability of MALDI-MS to perform both qualitative and quantitative analyses of anthocyanins

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Protocols

Mass Spectrometry of Glycans

The development of modern mass spectrometry (MS) equipment with high resolution and mass accuracy has led to its use in analyzing glycans for both profiling and structural studies.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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