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Merck
CN

92732

Supelco

Trimethylsulfonium hydroxide solution

~0.25 M in methanol, derivatization grade (GC derivatization), LiChropur™

Synonym(s):

TMSH

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About This Item

Linear Formula:
(CH3)3S(OH)
CAS Number:
17287-03-5
Molecular Weight:
94.18
Beilstein:
3910286
MDL number:
MFCD00216756
UNSPSC Code:
12352200
PubChem Substance ID:
329770161
NACRES:
NA.22

Key Documents

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grade

derivatization grade (GC derivatization)

Quality Level

100

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Alkylations

packaging

pkg of 10 × 1 mL

concentration

~0.25 M in methanol

technique(s)

gas chromatography (GC): suitable

storage temp.

2-8°C

SMILES string

[OH-].C[S+](C)C

InChI

1S/C3H9S.H2O/c1-4(2)3;/h1-3H3;1H2/q+1;/p-1

InChI key

MDTPTXSNPBAUHX-UHFFFAOYSA-M

Related Categories

General description

Trimethylsulfonium hydroxide (TMSH) is a methylating reagent. It can be prepared by dissolving trimethylsulfonium iodide in methanol and water solvent further treating with silver oxide.

Application

TMSH solution has been used as a derivatizing agent in a study to determine the fatty acids in milk samples using thermochemolysis-gas chromatography-mass spectrometry.

Other Notes

Reagent for the methylation of nucleophiles, e.g. carboxylic acids, alcohols, thiols, N-heterocycles; Rapid derivatization of acids for GC by pre-column transesterification of glycerides

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

51.8 °F - closed cup

Flash Point(C)

11 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCM5828
BCCK2512
BCCG6745
BCCD6022
BCCB9475

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Raimund Nagel et al.
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K. Yamauchi et al.
The Journal of Organic Chemistry, 44, 638-638 (1979)
Sandra Meyer et al.
Journal of animal science and biotechnology, 11, 20-20 (2020-03-12)
The hypothesis was tested that insect meal (IM) as protein source influences intermediary metabolism of growing pigs. To test this, 30 male, 5-week-old crossbred pigs were randomly assigned to 3 groups of 10 pigs each with similar body weights (BW)
Lidia Lipińska et al.
Probiotics and antimicrobial proteins, 10(2), 186-200 (2017-11-08)
The antifungal activity of Lactobacillus pentosus ŁOCK 0979 depends both on the culture medium and on the fungal species. In the control medium, the strain exhibited limited antagonistic activity against indicator food-borne molds and yeasts. However, the supplementation of the
K.D. Muller et al.
Chromatographia, 30, 245-245 (1990)
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