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Merck
CN

93420

Triton™ X-100

non-ionic detergent

Synonym(s):

t-Octylphenoxypolyethoxyethanol, Polyethylene glycol tert-octylphenyl ether

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About This Item

Linear Formula:
t-Oct-C6H4-(OCH2CH2)xOH, x= 9-10
CAS Number:
9036-19-5
PubChem Substance ID:
329770231
UNSPSC Code:
12161900
Beilstein/REAXYS Number:
2315025
MDL number:
MFCD00128254

Key Documents

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SMILES string

CC(C)(C)CC(C)(C)c1ccc(OCCOCCOCCOCCOCCOCCOCCO)cc1

InChI

1S/C28H50O8/c1-27(2,3)24-28(4,5)25-6-8-26(9-7-25)36-23-22-35-21-20-34-19-18-33-17-16-32-15-14-31-13-12-30-11-10-29/h6-9,29H,10-24H2,1-5H3

InChI key

HNLXNOZHXNSSPN-UHFFFAOYSA-N

description

non-ionic

form

liquid

mol wt

micellar avg mol wt 80,000, average mol wt 625

refractive index

n20/D 1.490-1.494

CMC

0.2-0.9 mM (20-25°C)

transition temp

cloud point 63-69 °C (1%; demin. water), pour point ~7 °C

solubility

water: soluble

density

1.065 g/mL at 20 °C

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Biochem/physiol Actions

Widely used non-ionic surfactant for recovery of membrane components under mild non-denaturing conditions.

Other Notes

Non-ionic detergent used in the preparation of acetylcholine-receptor protein

Legal Information

Triton is a trademark of The Dow Chemical Company or an affiliated company of Dow

Disclaimer

may become turbid on storage

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

483.8 °F - closed cup

flash_point_c

251 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

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Large-scale purification of the acetylcholine-receptor protein in its membrane-bound and detergent-extracted forms from Torpedo marmorata electric organ.
A Sobel et al.
European journal of biochemistry, 80(1), 215-224 (1977-10-17)
Caroline Contat et al.
eLife, 9 (2020-06-24)
Glucose utilization increases in tumors, a metabolic process that is observed clinically by 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET). However, is increased glucose uptake important for tumor cells, and which transporters are implicated in vivo? In a genetically-engineered mouse model of
Friederike Pfeiffer et al.
Acta neuropathologica, 122(5), 601-614 (2011-10-11)
In experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis (MS), loss of the blood-brain barrier (BBB) tight junction (TJ) protein claudin-3 correlates with immune cell infiltration into the CNS and BBB leakiness. Here we show that sealing BBB
Jing Cui et al.
Experimental eye research, 88(3), 438-444 (2008-11-27)
Previous investigators reported that epiretinal membranes isolated from patients with proliferative vitreoretinopathy (PVR) express various platelet-derived growth factor (PDGF) family members and PDGF receptors (PDGFRs) (Cui, J.Z., Chiu, A., Maberley, D., Ma, P., Samad, A., Matsubara, J.A., 2007. Stage specificity
Andri K Riau et al.
Molecular vision, 15, 335-342 (2009-02-19)
Pterygium is an ocular surface disease of unknown etiology associated with epithelial and fibrovascular outgrowth from the conjunctiva onto the cornea. S100 proteins are calcium-activated signaling proteins that interact with other proteins to modulate biological functions such as cell migration
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