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Merck
CN

936812

sSPhos Pd G2 ChemBeads

new

5 wt% loading

Synonym(s):

Chloro(sodium-2-dicyclohexylphosphino-2′,6′-dimethoxy-1,1′-biphenyl-3′-sulfonate)[2-(2′-amino-1,1′-biphenyl)]palladium(II) ChemBeads

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About This Item

Empirical Formula (Hill Notation):
C38H44ClNO5PPdS·Na
CAS Number:
2375242-78-5
Molecular Weight:
822.66
UNSPSC Code:
12352100

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form

beads

Quality Level

100

composition

loading, 4-6 wt. %
5 wt% loading

reaction suitability

reagent type: catalyst
core: palladium
reaction type: Cross Couplings

color

white to beige-brown

SMILES string

[Na+].Nc1ccccc1-c2ccccc2[Pd]Cl.COc3ccc(c(OC)c3-c4ccccc4P(C5CCCCC5)C6CCCCC6)S([O-])(=O)=O

InChI

1S/C26H35O5PS.C12H10N.ClH.Na.Pd/c1-30-22-17-18-24(33(27,28)29)26(31-2)25(22)21-15-9-10-16-23(21)32(19-11-5-3-6-12-19)20-13-7-4-8-14-20;13-12-9-5-4-8-11(12)10-6-2-1-3-7-10;;;/h9-10,15-20H,3-8,11-14H2,1-2H3,(H,27,28,29);1-6,8-9H,13H2;1H;;/q;;;2*+1/p-2

InChI key

MWQYWXJKMDRSJN-UHFFFAOYSA-L

General description

The ChemBeads product of the Buchwald second generation palladacycle bearing the sSPhos ligand. sSPhos Pd G2 can be used as a water-soluble Pd-precatalyst in a range of cross-coupling reaction, including:
  • DNA-compatible Suzuki-Miyaura reaction between DNA-linked aryl halides and various boronic acids/esters including heteroaryl boronates.
  • DNA-compatible hydroxycarbonylation reactions.
  • The cross-coupling reaction between boronic ester and brominated cyclic nucleotide to synthesize cyclic adenosine and guanosine monophosphate in the presence of potassium phosphate and hydrochloric acid.
  • The Palladium-Mediated Carbonylative Suzuki Coupling for DNA-Encoded Library Synthesis
  • In Multiplexed CuAAC Suzuki–Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling
Loaded at 5% wt. on glass beads for use in high-throughput expermentation (HTE).

Application

ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.

For general uses, product is also available in powdered form (763314 )

Features and Benefits

ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.

Regulatory Information

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