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Merck
CN

95193

Sigma-Aldrich

Cap A (acetic anhydride 10% in THF/lutidine 8 : 1)

suitable for DNA synthesis

Synonym(s):

Acetic anhydride solution

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About This Item

CAS Number:
108-24-7
MDL number:
MFCD00008705
UNSPSC Code:
12352200

Key Documents

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technique(s)

DNA synthesis: suitable

impurities

≤0.005% water

density

0.911 g/mL at 20 °C

SMILES string

CC(=O)OC(C)=O

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Application

Reagent used in the phosphite triester method of oligonucleotide synthesis for the capping of the remaining free 5′-hydroxyl groups by acetylation. Reagent is suitable for use on ABI, Beckman synthesizers.

Preparation Note

filtered with a 0.1 μm filter

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

EUH019

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

1.4 °F - closed cup

Flash Point(C)

-17.0 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

易制毒化学品（2类）
危险化学品
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In-Taek Hwang et al.
Molecules (Basel, Switzerland), 16(8), 6313-6321 (2011-07-28)
An efficient synthesis of 4-arylcoumarins has been accomplished via Kostanecki reactions of 2-hydroxybenzophenones with acetic anhydride employing DBU at ambient temperature. Using the same strategy, several 2-acyloxybenzophenone derivatives were readily converted to 3,4-difunctionalized coumarins. This protocol offers a notable improvement
Chunyan Hu et al.
Journal of agricultural and food chemistry, 59(19), 10517-10523 (2011-09-03)
Poultry feathers are renewable resources, inexpensive and abundantly available, but have limited applications. Although keratin extracted from feathers has been chemically modified, there are no reports on the chemical modification or development of thermoplastics from poultry feathers. Acetylation is an
Manuel Weber et al.
The Journal of organic chemistry, 77(23), 10846-10855 (2012-12-01)
A multicomponent reaction is reported generating highly enantioenriched and diastereomerically pure quaternary amino acid derivatives via 1,4-addition of azlactones to enones. The azlactone intermediates are generated in situ from unprotected α-amino acids and acetic anhydride. Previous attempts using bis-palladacycle catalysts
Rie Ito et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(31), 3714-3720 (2011-11-01)
A simple, rapid and sensitive method termed dispersive liquid-liquid microextraction (DLLME) combined with gas chromatography-mass spectrometry (GC/MS) was developed for the determination of tricyclic antidepressants (TCAs) in human urine sample. An appropriate mixture of methanol (disperser solvent), carbon tetrachloride (extraction
Cledualdo Soares de Oliveira et al.
Molecules (Basel, Switzerland), 17(5), 5095-5107 (2012-05-05)
Five new 1-(2-(5-nitrofuran-2-yl)-5-(aryl)-1,3,4-oxadiazol-3-(2H)-yl) ethanone compounds 5a-e were synthesized by cyclization of N-acylhydrazones 4a-e with acetic anhydride under reflux conditions. Their structures were fully characterized by IR, ¹H-NMR, and ¹³C-NMR. Furthermore, evaluations of the antibacterial activity of the 1,3,4-oxadiazoles 5a-e and
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