97090
Z-Pro-OH
puriss., ≥99.0% (T)
Synonym(s):
Z-L-Proline
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About This Item
Empirical Formula (Hill Notation):
C13H15NO4
CAS Number:
Molecular Weight:
249.26
EC Number:
214-557-4
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
88579
MDL number:
grade
puriss.
assay
≥99.0% (T)
optical activity
[α]20/D −60±1°, c = 5% in acetic acid
mp
75-77 °C, 76-78 °C (lit.)
SMILES string
N.OP(O)(O)=O, OC(=O)[C@@H]1CCCN1C(=O)OCc2ccccc2
InChI
1S/C13H15NO4/c15-12(16)11-7-4-8-14(11)13(17)18-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,15,16)/t11-/m0/s1
InChI key
JXGVXCZADZNAMJ-NSHDSACASA-N
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma.
Ling Tang et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 24(2), 474-485 (2017-11-01)
Cytotoxicity of carbobenzoxy-protected amino acids.
M Dolenga et al.
In vitro cellular & developmental biology : journal of the Tissue Culture Association, 28A(5), 300-302 (1992-05-01)
Sachin Mittal et al.
Pharmaceutical research, 24(7), 1290-1298 (2007-03-23)
To determine the bioactivation and uptake of prolidase-targeted proline prodrugs of melphalan in six cancer cell lines with variable prolidase expression and to evaluate prolidase-dependence of prodrug cytotoxicity in the cell lines compared to that of the parent drug, melphalan.
Anna Lupi et al.
Biochimica et biophysica acta, 1744(2), 157-163 (2005-05-10)
Prolidase deficiency (PD) is a recessive disorder of the connective tissue caused by mutations in the prolidase, a specific peptidase, cleaving the dipeptides with a C-terminal prolyl and hydroxyprolyl residue. PD is a complex syndrome characterized mainly by intractable skin
Arkadiusz Surazynski et al.
European journal of pharmacology, 649(1-3), 115-119 (2010-09-28)
Transforming growth factor beta 1 (TGF β1) is a protein that in most cells control proliferation and differentiation. One of the best characterized functions of TGF β1 is stimulation of collagen biosynthesis that may lead to tissue fibrosis. Several reports
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