Skip to Content
Merck
CN

Key Documents

View All Documentation

A9797

Ambroxol hydrochloride

analytical standard

Synonym(s):

2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C13H18Br2N2O · HCl
CAS Number:
23828-92-4
Molecular Weight:
414.56
NACRES:
NA.24
PubChem Substance ID:
329771060
UNSPSC Code:
41116107
EC Number:
245-899-2
MDL number:
MFCD00078932
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

grade

analytical standard

Quality Level

100

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

Cl.Nc1c(Br)cc(Br)cc1CN[C@@H]2CC[C@@H](O)CC2

InChI

1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H/t10-,11-;

InChI key

QNVKOSLOVOTXKF-PFWPSKEQSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Ambroxol hydrochloride is a mucolytic expectorant and a metabolite of bromhexine. It is used in the treatment of respiratory disorders characterized by viscous or excessive mucus.

Application

Ambroxol hydrochloride standard may be used as a reference standard in the determination of ambroxol hydrochloride in pharmaceutical preparations using reversed-phase sequential injection chromatography (RP-SIC) and reversed-phase high performance liquid chromatography (RP-HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Metabolite of bromhexine.
A Nav1.8-preferring sodium channel blocker

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCN2756
BCCK2854
BCCF5777
BCCB1637
BCBX6021

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Jauch, R., et al.
Arzneimittelforschung, 13, 474-474 (1963)
Wolfram Gaida et al.
Neuropharmacology, 49(8), 1220-1227 (2005-09-27)
Neuropathic pain affects many patients, and treatment today is far from being perfect. Nav1.8 Na(+) channels, which are expressed by small fibre sensory neurons, are promising targets for novel analgesics. Na(+) channel blockers used today, however, show only limited selectivity
Concise Dictionary of Pharmacological Agents: Properties and Synonyms (2012)
Sequential injection chromatographic determination of ambroxol hydrochloride and doxycycline in pharmaceutical preparations.
Satinsky D, et al.
Talanta, 68(2), 214-218 (2005)
Giovanni Ciana et al.
Molecular genetics and metabolism reports, 25, 100678-100678 (2020-12-10)
Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the acid β-glucosidase encoding gene (GBA1), resulting in the deficient activity of acid β-glucosidase (GCase). To date, there is no approved treatment for the neurological manifestations
View All Related Papers

Global Trade Item Number

SKUGTIN
A9797-5G04061835504534

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service