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Merck
CN

D7512

Dyclonine hydrochloride

Synonym(s):

1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone

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About This Item

Empirical Formula (Hill Notation):
C18H27NO2 · HCl
CAS Number:
536-43-6
Molecular Weight:
325.87
UNSPSC Code:
41116107
PubChem Substance ID:
24894136
EC Number:
208-633-6
MDL number:
MFCD00035386

Key Documents

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technique(s)

HPLC: suitable, gas chromatography (GC): suitable

format

neat

SMILES string

Cl.CCCCOc1ccc(cc1)C(=O)CCN2CCCCC2

InChI

1S/C18H27NO2.ClH/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19;/h7-10H,2-6,11-15H2,1H3;1H

InChI key

KNZADIMHVBBPOA-UHFFFAOYSA-N

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Rapid onset local anesthetic that is absorbed through skin

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

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Nonprescription drug screening. Dyclonine hydrochloride.
L A Nelson
American pharmacy, NS27(9), 27-29 (1987-09-01)
Dyclonine hydrochloride, local anaesthetic allergic contact dermatitis.
H I Maibach
Contact dermatitis, 14(2), 114-114 (1986-02-01)
Andrea C Schmidt
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 25(4-5), 407-416 (2005-05-18)
Two homologous local anaesthetic drugs, falicaine (propipocaine) hydrochloride (1-(4-propoxyphenyl)-3-(1-piperidinyl)-1-propanone hydrochloride, PPCHC) and dyclonine hydrochloride (1-(4-butoxyphenyl)-3-(1-piperidinyl)-1-propanone hydrochloride, DCNHC) were characterized by thermal analysis (hot-stage-microscopy, differential scanning calorimetry, thermogravimetry), vibrational spectroscopic methods (FTIR-, FT-Raman-spectroscopy), powder X-ray diffractometry, solid-state-/solution-NMR and water-vapor sorption analysis.
C Y Liang et al.
Journal of pharmaceutical sciences, 84(9), 1141-1143 (1995-09-01)
Dyclonine hydrochloride, a local anesthetic, is known to degrade in aqueous media. In this paper, the isolation and characterization of two major degradation products, formed by heating of an aqueous solution of dyclonine hydrochloride for 2 weeks at 50 degrees
X H Liao et al.
Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 25(6), 585-586 (2003-01-09)
The paper deals with the composition, preparation and qualitative control of compound Dyclonine's suspending mixture, one of gastroscopic mucomembranous anesthetics. The content of Dyclonine hydrochloride was detected by ultraviolet spectrophotometry. It shows that the average rate of recovery is 100.80%
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