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Merck
CN

D7512

Dyclonine hydrochloride

Synonym(s):

1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone

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About This Item

Empirical Formula (Hill Notation):
C18H27NO2 · HCl
CAS Number:
536-43-6
Molecular Weight:
325.87
UNSPSC Code:
41116107
PubChem Substance ID:
24894136
EC Number:
208-633-6
MDL number:
MFCD00035386

Key Documents

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technique(s)

HPLC: suitable, gas chromatography (GC): suitable

format

neat

SMILES string

Cl.CCCCOc1ccc(cc1)C(=O)CCN2CCCCC2

InChI

1S/C18H27NO2.ClH/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19;/h7-10H,2-6,11-15H2,1H3;1H

InChI key

KNZADIMHVBBPOA-UHFFFAOYSA-N

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Rapid onset local anesthetic that is absorbed through skin

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

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Nonprescription drug screening. Dyclonine hydrochloride.
L A Nelson
American pharmacy, NS27(9), 27-29 (1987-09-01)
Dyclonine hydrochloride, local anaesthetic allergic contact dermatitis.
H I Maibach
Contact dermatitis, 14(2), 114-114 (1986-02-01)
Andrea C Schmidt
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 25(4-5), 407-416 (2005-05-18)
Two homologous local anaesthetic drugs, falicaine (propipocaine) hydrochloride (1-(4-propoxyphenyl)-3-(1-piperidinyl)-1-propanone hydrochloride, PPCHC) and dyclonine hydrochloride (1-(4-butoxyphenyl)-3-(1-piperidinyl)-1-propanone hydrochloride, DCNHC) were characterized by thermal analysis (hot-stage-microscopy, differential scanning calorimetry, thermogravimetry), vibrational spectroscopic methods (FTIR-, FT-Raman-spectroscopy), powder X-ray diffractometry, solid-state-/solution-NMR and water-vapor sorption analysis.
N B Choudry et al.
The European respiratory journal, 3(5), 579-583 (1990-05-01)
Cough and airway constriction are common features of respiratory diseases. Both can be caused by stimulation of airway nerves. We have studied the effects of airway anaesthesia on these reflexes, stimulated by inhaled capsaicin, in order to determine whether they
S Weinstein et al.
The International journal of neuroscience, 54(1-2), 125-132 (1990-09-01)
The hypothesis that deficits in orotactile sensitivity may affect gustation and palatability is not new. It is supported by animal models employing deafferentation; however, little direct evidence supports the application of the model to humans. Indirect evidence comes from four
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