H6878
8-Hydroxyquinoline
Synonym(s):
8-Quinolinol, 8-Hydroxyquinoline, 8-Oxychinolin, Oxine
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About This Item
Empirical Formula (Hill Notation):
C9H7NO
CAS Number:
Molecular Weight:
145.16
UNSPSC Code:
12352005
NACRES:
NA.21
PubChem Substance ID:
EC Number:
205-711-1
Beilstein/REAXYS Number:
114512
MDL number:
assay
≥98.5%
Quality Level
form
powder (or crystalline powder or flakes)
mp
72.5-74.0 °C
antibiotic activity spectrum
fungi
mode of action
DNA synthesis | interferes, enzyme | inhibits
SMILES string
Oc1cccc2cccnc12
InChI
1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H
InChI key
MCJGNVYPOGVAJF-UHFFFAOYSA-N
General description
Chemical structure: quinolone
Application
Used as a lipophilic monoprotic bidentate chelating agent.
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signalword
Danger
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Michael Riedelberger et al.
Cell host & microbe, 27(3), 454-466 (2020-02-23)
Type I interferons (IFNs-I) fulfil multiple protective functions during pathogenic infections, but they can also cause detrimental effects and enhance immunopathology. Here, we report that IFNs-I promote the dysregulation of iron homeostasis in macrophages during systemic infections with the intracellular
Saverio Tardito et al.
Journal of medicinal chemistry, 55(23), 10448-10459 (2012-11-23)
This study reports the structure-activity relationship of a series of 8-hydroxoquinoline derivatives (8-HQs) and focuses on the cytotoxic activity of 5-Cl-7-I-8-HQ (clioquinol, CQ) copper complex (Cu(CQ)). 8-HQs alone cause a dose-dependent loss of viability of the human tumor HeLa and
Erik H J G Aarntzen et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 19(6), 1525-1533 (2013-02-06)
Anticancer dendritic cell (DC) vaccines require the DCs to relocate to lymph nodes (LN) to trigger immune responses. However, these migration rates are typically very poor. Improving the targeting of ex vivo generated DCs to LNs might increase vaccine efficacy
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H6878-100G | 04061833802274 |
| H6878-500G | 04061833802342 |
| H6878-25G | 04061833802281 |