H6878
8-Hydroxyquinoline
Synonym(s):
8-Quinolinol, 8-Hydroxyquinoline, 8-Oxychinolin, Oxine
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About This Item
Empirical Formula (Hill Notation):
C9H7NO
CAS Number:
Molecular Weight:
145.16
UNSPSC Code:
12352005
NACRES:
NA.21
PubChem Substance ID:
EC Number:
205-711-1
Beilstein/REAXYS Number:
114512
MDL number:
assay
≥98.5%
Quality Level
form
powder (or crystalline powder or flakes)
mp
72.5-74.0 °C
antibiotic activity spectrum
fungi
mode of action
DNA synthesis | interferes, enzyme | inhibits
SMILES string
Oc1cccc2cccnc12
InChI
1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H
InChI key
MCJGNVYPOGVAJF-UHFFFAOYSA-N
General description
Chemical structure: quinolone
Application
Used as a lipophilic monoprotic bidentate chelating agent.
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signalword
Danger
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Michael Riedelberger et al.
Cell host & microbe, 27(3), 454-466 (2020-02-23)
Type I interferons (IFNs-I) fulfil multiple protective functions during pathogenic infections, but they can also cause detrimental effects and enhance immunopathology. Here, we report that IFNs-I promote the dysregulation of iron homeostasis in macrophages during systemic infections with the intracellular
María Isabel Fernández-Bachiller et al.
Journal of medicinal chemistry, 53(13), 4927-4937 (2010-06-16)
Tacrine and PBT2 (an 8-hydroxyquinoline derivative) are well-known drugs that inhibit cholinesterases and decrease beta-amyloid (Abeta) levels by complexation of redox-active metals, respectively. In this work, novel tacrine-8-hydroxyquinoline hybrids have been designed, synthesized, and evaluated as potential multifunctional drugs for
Saverio Tardito et al.
Journal of medicinal chemistry, 55(23), 10448-10459 (2012-11-23)
This study reports the structure-activity relationship of a series of 8-hydroxoquinoline derivatives (8-HQs) and focuses on the cytotoxic activity of 5-Cl-7-I-8-HQ (clioquinol, CQ) copper complex (Cu(CQ)). 8-HQs alone cause a dose-dependent loss of viability of the human tumor HeLa and
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H6878-100G | 04061833802274 |
| H6878-500G | 04061833802342 |
| H6878-25G | 04061833802281 |