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Merck
CN

H8760

Hydroflumethiazide

analytical standard, ~97%

Synonym(s):

3,4-Dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

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About This Item

Empirical Formula (Hill Notation):
C8H8F3N3O4S2
CAS Number:
135-09-1
Molecular Weight:
331.29
UNSPSC Code:
41116107
PubChem Substance ID:
329815253
EC Number:
205-173-8
MDL number:
MFCD00057316

Key Documents

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grade

analytical standard

assay

~97%

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

O=S1(C2=CC(S(=O)(N)=O)=C(C(F)(F)F)C=C2NCN1)=O

InChI

1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)

InChI key

DMDGGSIALPNSEE-UHFFFAOYSA-N

Gene Information

human ... SLC12A3(6559)

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General description

Hydroflumethiazide is a thiazide diuretic drug, which acts like a potent antihypertensive agent. It is used in combination with spironolactone to minimize the excessive loss of potassium in hypokalemic patients who require diuretic therapy.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Hydroflumethiazide may be used as a reference standard in the determination of hydroflumethiazide in urine samples using micellar liquid chromatography coupled with fluorimetry detector (MLC).

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

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B Maharaj et al.
Journal of human hypertension, 7(5), 447-450 (1993-10-01)
This randomised, double-blind study compared the efficacy and safety of a fixed combination of hydroflumethiazide 50 mg and reserpine 0.125 mg (H-R) and chlortalidone 12.5 mg and atenolol 50 mg (C-A) in adult black patients with mild to moderate hypertension
S Suzuki et al.
No to shinkei = Brain and nerve, 38(2), 155-161 (1986-02-01)
The susceptibility to cerebral ischemia was studied in stroke-resistant spontaneously hypertensive rats (SHRSR) treated by a long-term antihypertensive treatment, and compared with untreated SHRSR and Wistar rats (WR). Male SHRSR, aged 8 weeks, were divided into two groups and a
X Liu et al.
Biopharmaceutics & drug disposition, 18(2), 93-101 (1997-03-01)
The objective of this work was to develop a simple residual method to estimate the rate constant for actual or apparent zero-order absorption into a one-compartment model. The method is based on the fact that, in theory, a plot of
Chromatographic determination of diuretics in urine samples using hybrid micellar mobile phases with fluorimetric detection.
Carda-Broch.S, et al.
Analytica Chimica Acta, 375(1-2), 143-154 (1998)
G O Yonga et al.
East African medical journal, 70(11), 696-700 (1993-11-01)
In a prospective single-blind comparative trial, sixty newly diagnosed mild to moderate hypertensives were randomly assigned to either propranolol or hydroflumethiazide monotherapy. Baseline fasting serum glucose lipid profiles, serum uric acid and potassium levels, were determined at the beginning of
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