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Merck
CN

H8760

Hydroflumethiazide

analytical standard, ~97%

Synonym(s):

3,4-Dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

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About This Item

Empirical Formula (Hill Notation):
C8H8F3N3O4S2
CAS Number:
135-09-1
Molecular Weight:
331.29
UNSPSC Code:
41116107
PubChem Substance ID:
329815253
EC Number:
205-173-8
MDL number:
MFCD00057316

Key Documents

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InChI key

DMDGGSIALPNSEE-UHFFFAOYSA-N

InChI

1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)

SMILES string

O=S1(C2=CC(S(=O)(N)=O)=C(C(F)(F)F)C=C2NCN1)=O

grade

analytical standard

assay

~97%

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Gene Information

human ... SLC12A3(6559)

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General description

Hydroflumethiazide is a thiazide diuretic drug, which acts like a potent antihypertensive agent. It is used in combination with spironolactone to minimize the excessive loss of potassium in hypokalemic patients who require diuretic therapy.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Hydroflumethiazide may be used as a reference standard in the determination of hydroflumethiazide in urine samples using micellar liquid chromatography coupled with fluorimetry detector (MLC).

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

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B Maharaj et al.
Journal of human hypertension, 7(5), 447-450 (1993-10-01)
This randomised, double-blind study compared the efficacy and safety of a fixed combination of hydroflumethiazide 50 mg and reserpine 0.125 mg (H-R) and chlortalidone 12.5 mg and atenolol 50 mg (C-A) in adult black patients with mild to moderate hypertension
X Liu et al.
Biopharmaceutics & drug disposition, 18(2), 93-101 (1997-03-01)
The objective of this work was to develop a simple residual method to estimate the rate constant for actual or apparent zero-order absorption into a one-compartment model. The method is based on the fact that, in theory, a plot of
D Hillaire-Buys et al.
Diabetologia, 27(6), 583-586 (1984-12-01)
LN 5330 is a new benzothiadiazine which is a structural analogue of diazoxide. Its effects in vivo were studied on blood glucose levels and insulin, glucagon and somatostatin secretion in normal dogs, and in vitro on glucagon and insulin secretion
S Suzuki et al.
No to shinkei = Brain and nerve, 38(2), 155-161 (1986-02-01)
The susceptibility to cerebral ischemia was studied in stroke-resistant spontaneously hypertensive rats (SHRSR) treated by a long-term antihypertensive treatment, and compared with untreated SHRSR and Wistar rats (WR). Male SHRSR, aged 8 weeks, were divided into two groups and a
K Hermansen et al.
Metabolism: clinical and experimental, 34(8), 784-789 (1985-08-01)
Treatment with thiazide diuretics causes an impairment of the glucose metabolism. To study whether this is due to a direct effect on the endocrine pancreas, the effects of the thiazide hydroflumethiazide on the release of glucagon, insulin, and somatostatin from
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