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Merck
CN

P5654

Piroxicam

≥98% (TLC)

Synonym(s):

4-Hydroxy-2-methyl-3-(pyrid-2-yl-carbamoyl)-2H-1,2-benzothiazine 1,1-dioxide

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About This Item

Empirical Formula (Hill Notation):
C15H13N3O4S
CAS Number:
36322-90-4
Molecular Weight:
331.35
NACRES:
NA.77
PubChem Substance ID:
24278641
UNSPSC Code:
41116107
EC Number:
252-974-3
MDL number:
MFCD00057317

Key Documents

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biological source

synthetic (organic)

Quality Level

100

assay

≥98% (TLC)

form

powder

storage temp.

2-8°C

SMILES string

CN1C(C(=O)Nc2ccccn2)=C(O)c3ccccc3S1(=O)=O

InChI

1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)

InChI key

QYSPLQLAKJAUJT-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742), PTGS2(5743)
rat ... Alox5(25290)

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Application

Piroxicam has been used:
  • for the induction of colitis in mice
  • as a non-steroidal anti-inflammatory drug to increase the sensitivity to gut injury in interleukin-10 (IL-10) knockout mice
  • as a chemopreventive agent and as a positive control to study its effects on tumor growth in mice small intestine

Biochem/physiol Actions

Cyclooxygenase inhibitor.
Piroxicam is a non‐steroidal anti‐inflammatory drug (NSAID). It possesses analgesic properties and exhibits therapeutic effects against rheumatic disorders.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H301,H373

Hazard Classifications

Acute Tox. 3 Oral - STOT RE 2 Oral

target_organs

Gastrointestinal tract

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000526618
0000526618
0000526617
0000526617
0000519523

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Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling
Lang M, et al.
Molecular Cancer, 12(1), 41-41 (2013)
Jiawei Guo et al.
Cell reports. Medicine, 4(1), 100881-100881 (2023-01-06)
Systematic bone loss is commonly complicated with inflammatory bowel diseases (IBDs) with unclear pathogenesis and uncertain treatment. In experimental colitis mouse models established by dextran sulfate sodium and IL-10 knockout induced with piroxicam, bone mass and quality are significantly decreased.
Michaela Lang et al.
Molecular cancer, 12(1), 41-41 (2013-05-15)
Patients with familial adenomatous polyposis (FAP) are at increased risk for the development of colorectal cancer. Surgery and chemoprevention are the most effective means to prevent cancer development. Thymoquinone (TQ) is considered the main compound of the volatile Nigella sativa
Seung-Won Choi et al.
Plant biotechnology (Tokyo, Japan), 39(3), 323-327 (2022-11-10)
Agrobacterium-mediated transformation is a key innovation for plant breeding, and routinely used in basic researches and applied biology. However, the transformation efficiency is often the limiting factor of this technique. In this study, we discovered that oxicam-type nonsteroidal anti-inflammatory drugs
T J Carty et al.
Prostaglandins, 19(1), 51-59 (1980-01-01)
The new non-steroidal antiinflammatory (NSAI)2 agent, piroxicam [4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide], is a highly active inhibitor of prostaglandin (PG) synthesis by methylcholanthrene transformed mouse fibroblasts (MC5-5) and rabbit synovial cells in culture. Comparison of the PG biosynthesis inhibitory activity of piroxicam with
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Global Trade Item Number

SKUGTIN
P5654-25G-A04061838174956
P5654-1G04061834392156
P5654-5G04061833429365
P5654-10G04061834392149
P5654-5G-A04061834392163

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