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P9380

Pyridoxamine dihydrochloride

Name: Pyridoxamine dihydrochloride
Brand: SIAL

analytical standard, ≥98%

Synonym(s):

4-(Aminomethyl)-5-hydroxy-6-methyl-3-pyridinemethanol dihydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₂N₂O₂ · 2HCl

CAS Number:

524-36-7

Molecular Weight:

241.11

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329820346

EC Number:

208-357-6

Beilstein/REAXYS Number:

3632748

MDL number:

MFCD00012808

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biological source

synthetic (organic)

Quality Level

200

grade

analytical standard

assay

≥98%

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

color

white to off-white

mp

224-226 °C (dec.) (lit.)

application(s)

vitamins, nutraceuticals, and natural products

format

neat

storage temp.

−20°C

SMILES string

Cl[H].Cl[H].Cc1ncc(CO)c(CN)c1O

InChI

1S/C8H12N2O2.2ClH/c1-5-8(12)7(2-9)6(4-11)3-10-5;;/h3,11-12H,2,4,9H2,1H3;2*1H

InChI key

HNWCOANXZNKMLR-UHFFFAOYSA-N

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Vitamin Standards

General description

Pyridoxamine dihydrochloride is a salt and amine form of pyridoxamine, which belongs to the family of vitamin B₆ compounds. Pyridoxamine occurs naturally in animal-based food products. Its deficiency in humans potentially causes sideroblastic anemia, weakness, insomnia, and neurological disorders. It has been reported to be effective against diabetic nephropathy.

Application

Pyridoxamine dihydrochloride analytical standard can be used as follows:

Combined analysis of eight water-soluble vitamins along with their different forms by liquid chromatography combined with isotope-dilution mass spectrometry (IDMS) in different fortified food samples
Simultaneous determination of eleven water-soluble B vitamins by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in ultrafiltrate samples
Multi-residue analysis of total thiamine, total riboflavin, total pyridoxine, and total niacin in infant formula and related nutritional products by enzymatic digestion followed by LC-MS-MS determination as per AOAC Official Method 2015.14
LC/MS-MS based assay of seven different vitamers of vitamin B₃ and vitamin B₆ in 40 human hair samples

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

WXBF6829V

0000478375

0000464741

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Pyridoxamine dihydrochloride in diabetic nephropathy (PIONEER-CSG-17): lessons learned from a pilot study

Dwyer JP, et al.

Nephron, 129(1), 22-28 (2015)

Mechanisms and regulation of intestinal absorption of water-soluble vitamins: cellular and molecular aspects

Physiology of the Gastrointestinal Tract, 407-407 (2016)

Nutritional diseases

Tropical Dermatology E-Book, 407-407 (2016)

Development of a LC-MS/MS method using stable isotope dilution for the quantification of individual B6 vitamers in fruits, vegetables, and cereals.

Thomas Bachmann et al.

Analytical and bioanalytical chemistry, 412(26), 7237-7252 (2020-08-17)

Vitamin B6 comprises an important set of molecules tightly interwoven with the human amino acid, fatty acid, and carbohydrate metabolism. Analytical methods striving for the quantification of individual B6 vitamers so far mostly rely on methods based on HPLC in

Global Trade Item Number

SKU	GTIN
P9380-1G	04061834402923
P9380-5G	04061835564392
P9380-25G	04061833653074

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