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P9422

Pramoxine hydrochloride

Name: Pramoxine hydrochloride
Brand: SIAL

analytical standard, ≥98%

Synonym(s):

4-[3-(4-Butoxyphenoxy)propyl]morpholine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₇NO₃ · HCl

CAS Number:

637-58-1

Molecular Weight:

329.86

NACRES:

NA.24

PubChem Substance ID:

329820349

UNSPSC Code:

41116107

EC Number:

211-293-1

MDL number:

MFCD00054323

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grade

analytical standard

Quality Level

100

assay

≥98%

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

Cl.CCCCOc1ccc(OCCCN2CCOCC2)cc1

InChI

1S/C17H27NO3.ClH/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18;/h5-8H,2-4,9-15H2,1H3;1H

InChI key

SYCBXBCPLUFJID-UHFFFAOYSA-N

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General description

Pramoxine hydrochloride is a surface and local anesthetic agent , which provides relief from itching and pain for a short period of time.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Topical anesthetic for skin or mucous membranes

pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Rapid high-performance liquid chromatographic determination of pramoxine hydrochloride in topical cream and suppositories.

Z L Chang et al.

Journal of chromatography, 291, 428-433 (1984-05-18)

Effect of topical pramoxine on experimentally induced pruritus in humans.

G Yosipovitch et al.

Journal of the American Academy of Dermatology, 37(2 Pt 1), 278-280 (1997-08-01)

High-pressure liquid chromatographic analysis of pramoxine hydrochloride in high lipoid aerosol foam dosage form.

R Weinberger et al.

Journal of pharmaceutical sciences, 69(4), 475-477 (1980-04-01)

A rapid and quantitative method for the determination of pramoxine hydrochloride by high-pressure liquid chromatography is presented. The drug is extracted as the salt from a preparation with a high lipoid composition by partitioning it to the aqueous phase of

Topical pramoxine and hydrocortisone foam versus placebo in relief of post partum episiotomy symptoms and wound healing.

I A Greer et al.

Scottish medical journal, 29(2), 104-106 (1984-04-01)

A double-blind randomised controlled trial, comparing pramoxine hydrochloride 1 per cent and hydrocortisone acetate 1 per cent in a mucoadhesive foam base, with simple aqueous foam (B.P.), in relieving episiotomy discomfort and episiotomy healing in 40 patients was carried out.

Canine and Feline Dermatology Drug Handbook (2012)

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Global Trade Item Number

SKU	GTIN
P9422-25G	04061833653081
P9422-10G	04061834403081

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