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PHR1134

Thymol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

2-Isopropyl-5-methylphenol, 5-Methyl-2-(1-methylethyl)phenol, 5-Methyl-2-isopropylphenol, IPMP

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About This Item

Linear Formula:
2-[(CH3)2CH]C6H3-5-(CH3)OH
CAS Number:
89-83-8
Molecular Weight:
150.22
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823154
EC Number:
201-944-8
Beilstein/REAXYS Number:
1907135
MDL number:
MFCD00002309

Key Documents

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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1449008

vapor pressure

1 mmHg ( 64 °C)

API family

thymol

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

bp

232 °C (lit.)

mp

48-51 °C (lit.)

density

0.965 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(C)c1ccc(C)cc1O

InChI

1S/C10H14O/c1-7(2)9-5-4-8(3)6-10(9)11/h4-7,11H,1-3H3

InChI key

MGSRCZKZVOBKFT-UHFFFAOYSA-N

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General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.

Application

Thymol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

Values of analytes vary lot to lot.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0147 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 2

flash_point_f

240.8 °F - closed cup

flash_point_c

116 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Spectrophotometric Determination of Thymol in Pharmaceuticla Formulations Via Oxidative Coupling Reaction
Mohammad, I Kh
Reactive functional Polymers, 17(3) (2005)
Antibacterial and antifungal activities of thymol: A brief review of the literature
Marchese A, et al.
Food Chemistry, 210, 402-414 (2016)
Spectrophotometric determination of thymol in pharmaceuticals with Gibb's reagent
Al-Neaimy, Usra IS
Journal of Educational Psychology, 22(39) (2009)
S P Lee et al.
British journal of pharmacology, 153(8), 1739-1749 (2008-03-13)
Thymol, a major component of thyme and oregano, has medical uses in oral care products as an astringent and antibiotic. Its distinctive sharp odour and pungent flavour are considered aversive properties. The molecular basis of these aversive properties is not
María C Elissondo et al.
Acta tropica, 125(3), 251-257 (2012-12-25)
Scolicidal solutions remain indispensable in the treatment of hydatid cyst disease. Properties of an ideal solution would be inexpensiveness and the promotion of a rapid and complete scolicidal effect with an absence of local and systemic side effects. From this
View All Related Papers

Global Trade Item Number

SKUGTIN
PHR1134-1G04061835237340

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