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PHR1285

Lovastatin

Name: Lovastatin
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Lovastatin, Mevinolin

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₃₆O₅

CAS Number:

75330-75-5

Molecular Weight:

404.54

UNSPSC Code:

41116107

NACRES:

NA.24

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Properties

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. L0790000, traceable to USP 1370600

API family

lovastatin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

-10 to -25°C

SMILES string

O1[C@@H](C[C@H](CC1=O)O)CC[C@@H]2[C@H]3[C@H](C[C@H](C=C3C=C[C@@H]2C)C)OC(=O)[C@H](CC)C

InChI

1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1

InChI key

PCZOHLXUXFIOCF-BXMDZJJMSA-N

Description

General description

Lovastatin, an orally administered drug, is a lactone metabolite used for the treatment of hypercholesterolemia and coronary heart diseases. It is a hexahydronaphtalene drug, belonging to the class of HMG-CoA (3-hydroxy-3-methyl-glutaryl-coenzyme A) reductase inhibitors.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Lovastatin may find its use as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometric, thermal characterization, and chromatographic techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC3329 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

GHS08

signalword

Warning

hcodes

H351,H361f

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Carc. 2 - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Two derivative spectrophotometric methods for the simultaneous determination of lovastatin combined with three antioxidants

Markopoulou CK and Koundourelllis JE

Journal of Pharmaceutical and Biomedical Analysis, 33(5), 1163-1173 (2003)

Thermal characterization of lovastatin in pharmaceutical formulations

Yoshida MI, et al.

Journal of Thermal Analysis and Calorimetry, 106(3), 657-664 (2011)

Instrumental analysis of potential lovastatin-Excipient interactions in preformulation studies

Ledeti I, et al.

Revista de Chimie (Bucharest, Romania), 66(22), 879-882 (2015)

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Global Trade Item Number

SKU	GTIN
PHR1285-1G	04061835233465