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Merck
CN

U5128

Urea

ACS reagent grade, ≤0.001% (Heavy Metals by ICP-OES, metals basis), 99.0-100.5%, solid

Synonym(s):

Carbamide, Carbonyldiamide

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About This Item

Linear Formula:
NH2CONH2
CAS Number:
57-13-6
Molecular Weight:
60.06
NACRES:
NA.21
PubChem Substance ID:
24900652
UNSPSC Code:
12352100
EC Number:
200-315-5
MDL number:
MFCD00008022
Beilstein/REAXYS Number:
635724
Assay:
≤0.001% (Heavy Metals by ICP-OES, metals basis), 99.0-100.5%
Form:
solid

Key Documents

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Product Name

Urea, ACS reagent, 99.0-100.5%

grade

ACS reagent

Quality Level

200

assay

≤0.001% (Heavy Metals by ICP-OES, metals basis), 99.0-100.5%

form

solid

impurities

≤0.01% Insoluble matter

ign. residue

≤0.01%

mp

132-135 °C (lit.)

solubility

H2O: soluble 480 g/L at 20 °C

density

1.335 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤5 ppm, sulfate (SO42-): ≤0.001%

cation traces

Fe: ≤0.001%

functional group

amine

SMILES string

NC(N)=O

InChI

1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)

InChI key

XSQUKJJJFZCRTK-UHFFFAOYSA-N

Gene Information

human ... CA1(759), CA2(760)
rat ... Ppm1a(24666)

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General description

Urea is a colourless organic compound, without any odour. It is easily soluble in water.

Application

Urea has been used:
  • to adjust the urea nitrogen concentration to a preferred range in blood reservoir for evaluating the dialyzer urea clearance
  • to prepare standards to measure urea synthesis
  • to prepare standards for blood urea nitrogen assay

Used for the denaturation of proteins and as a mild solubilization agent for insoluble or denatured proteins. Useful for renaturing proteins from samples already denatured with 6 M guanidine chloride such as inclusion bodies. May be used with guanidine hydrochloride and dithiothreitrol (DTT) in the refolding of denatured proteins into their native or active form.

Biochem/physiol Actions

Urea participates in the metabolism of nitrogenous substances. It serves as a nitrogen source, when used in fertilizers. Urea is used in manufacturing chemical compounds. It is widely used in the agricultural industry as a fertilizer as well as an animal feed additive, which is used as a nitrogen supplement in animal husbandry. Urea has adverse effects on seed germination, seedling growth and early plant growth in soil.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000534291
0000534289
0000534290
0000489451
0000527877

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Elimination of the adverse effects of urea fertilizer on seed germination, seedling growth, and early plant growth in soil
Bremner JM and Krogmeier MJ
Proceedings of the National Academy of Sciences of the USA, 85(13), 4601-4604 (1988)
Hepatic targeting and biodistribution of human fetal liver stem/progenitor cells and adult hepatocytes in mice
Cheng K, et al.
Hepatology, 50(4), 1194-1203 (2009)
Urea: Synthesis, Properties and Uses (2012)
CHAPTER 16 - METHODS OF FEEDING UREA TO LIVESTOCK
Urea As a Protein Supplement, 321-327 (1967)
Hemodialyzer mass transfer-area coefficients for urea increase at high dialysate flow rates
Leypoldt JK, et al.
Kidney International, 51(6), 2013-2017 (1997)
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The Carbon Enigma: Material Fundamentals and Retention Properties for Porous Graphitic Carbon (PGC) Stationary Phases

A shortened review of fundamentals of Porous Graphitic Carbon (PGC) materials. What they are and how do they work as a stationary phase material in HPLC?.

Global Trade Item Number

SKUGTIN
U5128-1KG04061835559893
U5128-5G04061837409738
U5128-100G04061835559886
U5128-500G04061835559909
U5128-5KG04061835559916

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