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About This Item
Empirical Formula (Hill Notation):
C10H17N · HCl
CAS Number:
Molecular Weight:
187.71
Beilstein:
4198854
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
grade
pharmaceutical primary standard
API family
amantadine
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
InChI
1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
InChI key
WOLHOYHSEKDWQH-SOVZANNPSA-N
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Amantadine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Biochem/physiol Actions
Dopamine releaser used to treat Parkinsonism and drug-induced extrapyramidal reactions.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Amantadine hydrochloride: current and new uses.
S de Roin et al.
The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 22(5), 322-325 (1990-10-01)
F Y Aoki et al.
Clinical pharmacokinetics, 14(1), 35-51 (1988-01-01)
Amantadine is a drug with diverse uses ranging from prevention of influenza A illness to the treatment of patients with Parkinson's disease. It is available only in oral formulations from which it is well absorbed and widely distributed, little drug
S Ito et al.
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 38(12), 897-902 (2001-03-14)
A virus infection was studied using half of the normal oral dose of amantadine hydrochloride-100 mg/d instead of 200 mg/d. The patients in this study, who visited the clinics during January and February 1999, were confirmed within 48 hours to
Bo OuYang et al.
Biochimica et biophysica acta, 1838(4), 1058-1067 (2013-09-24)
Many viral genomes encode small, integral membrane proteins that form homo-oligomeric channels in membrane, and they transport protons, cations, and other molecules across the membrane barrier to aid various steps of viral entry and maturation. These viral proteins, collectively named
Matias Rey-Carrizo et al.
Journal of medicinal chemistry, 57(13), 5738-5747 (2014-06-19)
Amantadine inhibits the M2 proton channel of influenza A virus, yet most of the currently circulating strains of the virus carry mutations in the M2 protein that render the virus amantadine-resistant. While most of the research on novel amantadine analogues
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