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Merck
CN

A0650000

Amobarbital

European Pharmacopoeia (EP) Reference Standard

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About This Item

Empirical Formula (Hill Notation):
C11H18N2O3
CAS Number:
57-43-2
Molecular Weight:
226.27
MDL number:
MFCD00057558
UNSPSC Code:
41116107
NACRES:
NA.24

Key Documents

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SMILES string

N1C(=O)NC(=O)C(C1=O)(CCC(C)C)CC

InChI

1S/C11H18N2O3/c1-4-11(6-5-7(2)3)8(14)12-10(16)13-9(11)15/h7H,4-6H2,1-3H3,(H2,12,13,14,15,16)

InChI key

VIROVYVQCGLCII-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

amobarbital

manufacturer/tradename

EDQM

drug control

kontrollierte Droge in Deutschland, regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIC (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Amobarbital EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品
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M Kurthen et al.
Der Radiologe, 33(4), 204-212 (1993-04-01)
In presurgical evaluation of epilepsy, unilateral cerebral inactivation by means of intracarotid injection of amobarbital is used for the determination of cerebral dominance for language and memory functions. This intracarotid amobarbital test (IAT) is intended to yield prognoses concerning postsurgical
Evidence-based practice: a reevaluation of the intracarotid amobarbital procedure (Wada test).
Sallie A Baxendale et al.
Archives of neurology, 65(6), 841-845 (2008-06-11)
Commentary: Epilepsia's Wada survey.
David Loring
Epilepsia, 55(12), 1891-1891 (2014-11-02)
Commentary: Epilepsia's Wada survey.
Andrew C Papanicolaou
Epilepsia, 55(12), 1890-1890 (2014-11-02)
S Brundert et al.
Der Radiologe, 33(4), 213-218 (1993-04-01)
Epileptic foci in the frontal or parieto-occipital cortex often cause epileptiform EEG changes in both hemispheres. Therefore, delineation of the primary epileptogenic area, which is necessary for epilepsy surgery, is not possible by electrophysiological methods. A temporary inactivation of the
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