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Merck
CN

A1320000

Aspartame

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Asp-Phe methyl ester, N-(L-α-Aspartyl)-L-phenylalanine methyl ester, Asp-Phe-OMe, Aspartame

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About This Item

Linear Formula:
HOOCCH2CH(NH2)CONHCH(CH2C6H5)COOCH3
CAS Number:
22839-47-0
Molecular Weight:
294.30
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329770357
MDL number:
MFCD00002724
Beilstein/REAXYS Number:
2223850

Key Documents

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Product Name

Aspartame, European Pharmacopoeia (EP) Reference Standard

InChI key

IAOZJIPTCAWIRG-QWRGUYRKSA-N

SMILES string

COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(O)=O

InChI

1S/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1

grade

pharmaceutical primary standard

agency

EP Reference Standard

API family

aspartame

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Application

Aspartame EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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M Maersk et al.
European journal of clinical nutrition, 66(4), 523-529 (2012-01-19)
Observational studies indicate that sugar-sweetened soft drinks (SSSD) may promote obesity, among other factors, owing to low-satiating effects. The effect of energy in drinks on appetite is still unclear. We examined the effect of two isocaloric, but macronutrient, different beverages
Jean-Daniel Berset et al.
Chemosphere, 88(5), 563-569 (2012-04-17)
A HPLC-MS/MS method is presented for the simultaneous determination of frequently used artificial sweeteners (ASs) and the main metabolite of aspartame (ASP), diketopiperazine (DKP), in environmental water samples using the direct-injection (DI) technique, thereby achieving limits of quantification (LOQ) of
Eva S Schernhammer et al.
The American journal of clinical nutrition, 96(6), 1419-1428 (2012-10-26)
Despite safety reports of the artificial sweetener aspartame, health-related concerns remain. We prospectively evaluated whether the consumption of aspartame- and sugar-containing soda is associated with risk of hematopoetic cancers. We repeatedly assessed diet in the Nurses' Health Study (NHS) and
B A Magnuson et al.
Critical reviews in toxicology, 37(8), 629-727 (2007-09-11)
Aspartame is a methyl ester of a dipeptide used as a synthetic nonnutritive sweetener in over 90 countries worldwide in over 6000 products. The purpose of this investigation was to review the scientific literature on the absorption and metabolism, the
Harriett H Butchko et al.
Regulatory toxicology and pharmacology : RTP, 35(2 Pt 2), S1-93 (2002-08-16)
Over 20 years have elapsed since aspartame was approved by regulatory agencies as a sweetener and flavor enhancer. The safety of aspartame and its metabolic constituents was established through extensive toxicology studies in laboratory animals, using much greater doses than
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