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About This Item
Empirical Formula (Hill Notation):
C22H24FN3O2
CAS Number:
Molecular Weight:
381.44
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24
SMILES string
Fc1ccc(cc1)C(=O)CCCN2CCC(CC2)[n]3c4c([nH][c]3=O)cccc4
InChI
1S/C22H24FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28)
InChI key
FEBOTPHFXYHVPL-UHFFFAOYSA-N
grade
pharmaceutical primary standard
API family
benperidol
manufacturer/tradename
EDQM
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Related Categories
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Benperidol EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Packaging
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
Other Notes
Sales restrictions may apply.
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Complete dopamine D2 receptor occupancy without extrapyramidal side effects under benperidol.
Carlos Schönfeldt-Lecuona et al.
Journal of clinical psychopharmacology, 24(1), 97-98 (2004-01-08)
S M Moerlein et al.
Nuclear medicine and biology, 22(6), 809-815 (1995-08-01)
[18F]Benperidol ([18F]BP), a positron-emitting analogue of the dopaminergic D2 antagonist benperidol, was evaluated as a radiopharmaceutical for use with positron emission tomography (PET). PET imaging of baboons after i.v. injection of [18F]BP indicated that the radiofluorinated ligand rapidly localized in
J Schröder et al.
Psychiatry research, 75(2), 115-123 (1997-11-14)
Recent studies have described a left lateralized striatal asymmetry of D2 dopamine receptors in male patients with schizophrenia. To replicate this finding and to explore its potential functional consequences, we investigated the D2 dopamine receptor system in 23 drug-naive patients
I Biryol et al.
Journal of pharmaceutical and biomedical analysis, 15(11), 1695-1701 (1997-07-01)
In this study two butyrophenones, droperidol and benperidol were voltammetrically investigated using platinum and specially activated glass carbon electrodes. The behaviours of the substance were investigated in various electrolyte solutions having different pH values and by different scan rates. As
J Schröder et al.
Fortschritte der Neurologie-Psychiatrie, 68 Suppl 1, S42-S45 (2000-07-25)
Animal and post mortem studies indicate that neuroleptic therapy may induce D2-dopamine receptor upregulation in the basal ganglia. To address this phenomenon in a clinical study, we investigated the D2-dopamine receptor binding in 15 DSM-III-R schizophrenics in the drug-naive state
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