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B0490000

Benzarone

Name: Benzarone
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone, NSC 82134

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₄O₃

CAS Number:

1477-19-6

Molecular Weight:

266.29

MDL number:

MFCD00867417

UNSPSC Code:

41116107

NACRES:

NA.24

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Properties

grade

pharmaceutical primary standard

API family

benzarone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[o]1c2c(c(c1CC)C(=O)c3ccc(cc3)O)cccc2

InChI

1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3

InChI key

RFRXIWQYSOIBDI-UHFFFAOYSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Benzarone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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High-performance liquid chromatographic comparison of in vivo and in vitro drug metabolism.

W Voelter et al.

Journal of chromatography, 290, 1-12 (1984-05-04)

Using 2-ethyl-3-(4- hydroxybenzoyl )benzofuran ( EHBB ) as an example, biotransformation in rabbits and rats and by rat hepatocyte suspensions was studied by high-performance liquid chromatography (HPLC) and mass spectrometry. The biotransformation of N-alkyl-substituted piperidines by rat hepatocytes gives valuable

The effects of antibiotics and uricosuric drugs on the renal elimination of methotrexate and 7-hydroxymethotrexate in rabbits.

H Iven et al.

Cancer chemotherapy and pharmacology, 21(4), 337-342 (1988-01-01)

In anesthetized rabbits, continuous infusion of methotrexate (MTX; 30 micrograms kg-1 min-1) established steady-state plasma concentrations for MTX and the metabolite 7-hydroxymethotrexate (7-OH-MTX) within 40 min. Fifty percent of the infused dose was eliminated unchanged by the kidneys and the

[Influence of 2-ethyl-3-(4-hydroxybenzoyl)-benzofuran (benzarone) on experimental atheromatosis (author's transl)].

J Roth et al.

Arzneimittel-Forschung, 30(11), 1897-1902 (1980-01-01)

Local transmural electrical stimulation by chronically implanted electrodes of a carotid artery in rabbits was daily repeated. The area in direct contact to the electrodes covered 0.5 x 5 mm of adventitia. The carotid walls received DC impulses (10 ms/imp

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Global Trade Item Number

SKU	GTIN
B0490000	04061833799321