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Merck
CN

B0760

Bufexamac

analytical standard

Synonym(s):

2-(p-Butoxyphenyl)acetohydroxamic acid

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About This Item

Empirical Formula (Hill Notation):
C12H17NO3
CAS Number:
2438-72-4
Molecular Weight:
223.27
NACRES:
NA.24
PubChem Substance ID:
329773128
UNSPSC Code:
41116107
EC Number:
219-451-1
MDL number:
MFCD00078936

Key Documents

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InChI

1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14)

InChI key

MXJWRABVEGLYDG-UHFFFAOYSA-N

SMILES string

CCCCOc1ccc(CC(=O)NO)cc1

grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

100

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General description

Bufexamac is a drug with antipyretic, analgesic and anti-inflammatory properties.

Application

Bufexamac may be used as a reference standard in the determination of bufexamac in pharmaceutical formulations using high-performance liquid chromatography (HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCBW0026
011M1532V
011M1532

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Contact dermatitis caused by bufexamac sparing the eruption of herpes zoster.
Hidetsugu Fukuda et al.
The Journal of dermatology, 39(4), 405-407 (2011-09-29)
S M Langan et al.
Clinical and experimental dermatology, 34(1), 20-25 (2008-10-03)
Many interventions have been described for inherited epidermolysis bullosa (EB), but it is unclear which are beneficial. A systematic review of randomized controlled trials (RCTs) was performed to inform practice and highlight research gaps. The Cochrane Central Register of Controlled
Acute generalized exanthematous pustulosis induced by bufexamac in an atopic girl.
H Belhadjali et al.
Contact dermatitis, 58(4), 247-248 (2008-03-21)
A Schnuch et al.
Deutsche medizinische Wochenschrift (1946), 130(50), 2881-2886 (2005-12-13)
Bufexamac is a non-steroidal, anti-inflammatory drug used in the topical treatment of atopic dermatitis, stasis dermatitis and perianal eczema. The substance is known to cause severe allergic contact dermatitis (ACD) as an adverse effect (AE), which may be indistinguishable from
Katrin Kügler et al.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 3(12), 979-986 (2006-01-13)
Anogenital dermatoses (AGD) are common and often very distressing. Clinically it is often unclear if allergic contact dermatitis or irritant dermatitis is involved. In order to optimize therapy and prophylaxis, it is essential to identify relevant allergens or irritants. Data
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