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Merck
CN

C0414

Clidinium bromide

analytical standard

Synonym(s):

3-Hydroxy-1-methylquinuclidinium bromide benzilate, 3-[(Hydroxydiphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane bromide

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About This Item

Empirical Formula (Hill Notation):
C22H26BrNO3
CAS Number:
3485-62-9
Molecular Weight:
432.35
NACRES:
NA.24
PubChem Substance ID:
329774786
UNSPSC Code:
41116107
EC Number:
222-471-3
MDL number:
MFCD00078996

Key Documents

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Product Name

Clidinium bromide, analytical standard

InChI key

WVDSMJSQJXGCNY-UHFFFAOYSA-N

InChI

1S/C22H26NO3.BrH/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19;/h2-11,17,20,25H,12-16H2,1H3;1H

SMILES string

Br.C[N]12CCC(CC1)C(C2)OC(=O)C(O)(c3ccccc3)c4ccccc4

grade

analytical standard

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

200

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Application

Clidinium bromide has been used as an analytical standard for the quantification of the analyte in pharmaceutical formulations using different analytical techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Clidinium bromide is an anticholinergic, antisecretory and antispasmodic drug, widely used in treating anxiety-related conditions and spastic colon by inhibiting the action of parasympathetic innervations thus decreasing the secretions of stomach acid and slowing the intestines.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

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H Valette et al.
European journal of pharmacology, 306(1-3), 133-138 (1996-06-13)
The muscarinic receptor antagonist methyl-quinuclidinyl-benzylate decreased myocardial beta-adrenoceptor density Bmax: 20.4 +/- 2.4 pmol/ml tissue versus 33.3 +/- 4 pmol/ml tissue in control dogs (P < 0.001), as assessed by using [11C]CGP-12177 (((2S)-4-(3-t-butyl-amino-2 hydroxypropoxy)-benzimidazol-2-one)) and positron emission tomography. In contrast
F Brunner et al.
British journal of pharmacology, 102(2), 373-380 (1991-02-01)
1. Muscarinic receptors on endothelial cells of bovine thoracic aorta were characterized by binding assays in which (-)-[3H]-N-methyl quinuclidinyl benzilate ([3H]-NMeQNB) was used as radioligand. 2. Binding of [3H]-NMeQNB to crude membranes of freshly isolated endothelial cells was atropine-displaceable and
Simultaneous determination of chlordiazepoxide and clidinium bromide in pharmaceutical formulations by derivative spectrophotometry
Toral I.M, et al.
The Veterinary Quarterly, 189(1), 67-74 (1999)
D Le Guludec et al.
Circulation, 90(1), 172-178 (1994-07-01)
Decreased myocardial adenylate cyclase activity in response to guanine nucleotide stimulation has been recently demonstrated in denervated myocardium of transplant patients, suggesting that changes in left ventricular muscarinic receptors may occur. The concentration and affinity constants of myocardial muscarinic receptors
H Yazawa et al.
The Journal of urology, 152(6 Pt 1), 2173-2177 (1994-12-01)
We obtained a primary culture of prostatic cells by an explant method from patients with benign prostatic hypertrophy (BPH). Ultrastructural morphology and growth characteristics of these cells conformed to those reported for smooth muscle cells isolated from vascular and visceral
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