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Merck
CN

C0414

Clidinium bromide

analytical standard

Synonym(s):

3-Hydroxy-1-methylquinuclidinium bromide benzilate, 3-[(Hydroxydiphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane bromide

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About This Item

Empirical Formula (Hill Notation):
C22H26BrNO3
CAS Number:
Molecular Weight:
432.35
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
222-471-3
MDL number:
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InChI key

WVDSMJSQJXGCNY-UHFFFAOYSA-N

InChI

1S/C22H26NO3.BrH/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19;/h2-11,17,20,25H,12-16H2,1H3;1H

SMILES string

Br.C[N]12CCC(CC1)C(C2)OC(=O)C(O)(c3ccccc3)c4ccccc4

grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

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General description

Clidinium bromide is an anticholinergic, antisecretory and antispasmodic drug, widely used in treating anxiety-related conditions and spastic colon by inhibiting the action of parasympathetic innervations thus decreasing the secretions of stomach acid and slowing the intestines.

Application

Clidinium bromide has been used as an analytical standard for the quantification of the analyte in pharmaceutical formulations using different analytical techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Certificates of Analysis (COA)

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C A Otto et al.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 18(5), 557-561 (1991-01-01)
The localization of quaternized muscarinic receptor (mAChR) antagonists, [11C]methyl tropanyl benzilate ([11C]MTRB) and [11C]methyl quinuclidinyl benzilate ([11C]MQNB), in rat pituitary was compared to that of [11C]tropanyl benzilate ([11C]TRB), a neutral antagonist. The quaternized ligands localize via a mAChR-mediated mechanism as
E Malatynska et al.
Brain research bulletin, 47(3), 285-290 (1998-12-29)
Three chimeric receptors stably expressed in murine fibroblast (B82) cells were used to examine how different parts of the rat muscarinic m1 and m2 receptors contribute to the down-regulation process. The MCH7 chimeric m2 receptor contained a fragment between VIth
Method development and validation of RP-HPLC method for simultaneous estimation of clidinium bromide, chlordiazepoxide and dicyclomine hydrochloride in bulk and combined tablet dosage forms
Doki.A and SK.K
International Journal of Pharma and Bio Sciences, 3(3), 152-161 (2013)
F J Ehlert et al.
The Journal of pharmacology and experimental therapeutics, 255(3), 1148-1157 (1990-12-01)
The distribution of subtypes of the muscarinic receptor in homogenates of the rat brain was investigated by measuring the competitive inhibition of the binding [3H]N-methylscopolamine by pirenzepine and AF-DX 116 (11[[2-[(diethylamino)methyl]-1-piperidinyl]acetyl]-5, 11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one). In most brain regions, the competitive binding curves
L Mei et al.
The Journal of pharmacology and experimental therapeutics, 251(1), 90-97 (1989-10-01)
We studied the relationship between the M1 muscarinic receptor density and the receptor-mediated hydrolysis of inositol lipids in cloned murine fibroblast B82 cells which were transfected with the m1 muscarinic receptor gene. Of the seven clones examined, the M1 muscarinic

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