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Merck
CN

C2040

Cloperastine hydrochloride

analytical standard

Synonym(s):

4-Chlorobenzhydryl 2-(1-piperidyl)ethyl ether

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About This Item

Empirical Formula (Hill Notation):
C20H24ClNO · HCl
CAS Number:
Molecular Weight:
366.32
UNSPSC Code:
41116107
PubChem Substance ID:
EC Number:
239-067-8
MDL number:
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Product Name

Cloperastine hydrochloride, analytical standard

InChI key

UNPLRYRWJLTVAE-UHFFFAOYSA-N

InChI

1S/C20H24ClNO.ClH/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22;/h1,3-4,7-12,20H,2,5-6,13-16H2;1H

SMILES string

Cl.Clc1ccc(cc1)C(OCCN2CCCCC2)c3ccccc3

grade

analytical standard

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

Application

Cloperastine hydrochloride may be used as an analytical standard for the quantification of cloperastine in biological samples using liquid chromatography coupled to tandem mass spectrometry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Certificates of Analysis (COA)

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L Allegra et al.
Arzneimittel-Forschung, 38(8), 1163-1166 (1988-08-01)
The results of 6 clinical trials involving a total of 174 patients are reported. Levodropropizine (S(-)-3-(4-phenyl-piperazin-1-yl)-propane-1,2-diol, DF 526) was compared in double-blind manner with placebo, morclofone and cloperastine. The antitussive activity and therapeutic efficacy of the drug were shown to
Antonia García et al.
Journal of pharmaceutical and biomedical analysis, 61, 230-236 (2012-01-10)
The classification of an impurity of a drug substance as genotoxic means that the "threshold of toxicological concern" (TTC) value of 1.5 μg/day intake, considered to be associated with an acceptable risk, should be the admissible limit in the raw
Gen Yamamoto et al.
Canadian journal of physiology and pharmacology, 87(11), 893-899 (2009-11-26)
We investigated the effects of the centrally acting antitussives dextromethorphan and cloperastine on urinary bladder dysfunction 24 h after cerebral infarction in rats using the cystometry technique. First, cystometrography was performed in conscious male Sprague-Dawley rats. Cerebral infarction was then
[Clinical study of a new antitussive: cloperastine].
D Olivieri et al.
Archivio Monaldi per la tisiologia e le malattie dell'apparato respiratorio, 38(5-6), 209-218 (1983-09-01)
[The pharmacologic activity of 1(2-(p-chloro-alpha-phenylbenzyloxy)ethyl)piperidine (cloperastine)].
G Canti et al.
Bollettino chimico farmaceutico, 122(8), 384-392 (1983-08-01)

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