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C4786

Cefoxitin sodium salt

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About This Item

Empirical Formula (Hill Notation):
C16H16N3NaO7S2
CAS Number:
33564-30-6
Molecular Weight:
449.43
NACRES:
NA.24
PubChem Substance ID:
329775070
UNSPSC Code:
41116107
EC Number:
251-574-6
MDL number:
MFCD00079042

Key Documents

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InChI key

GNWUOVJNSFPWDD-XMZRARIVSA-M

InChI

1S/C16H17N3O7S2.Na/c1-25-16(18-10(20)5-9-3-2-4-27-9)13(23)19-11(12(21)22)8(6-26-15(17)24)7-28-14(16)19;/h2-4,14H,5-7H2,1H3,(H2,17,24)(H,18,20)(H,21,22);/q;+1/p-1/t14-,16+;/m1./s1

SMILES string

[Na+].CO[C@]2(NC(=O)Cc1cccs1)C3SCC(COC(N)=O)=C(N3C2=O)C([O-])=O

form

powder or granules

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

storage temp.

2-8°C

Quality Level

200

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Application

The analytical standard can be used to:
  • Determine cefoxitin sodium using four stability-indicating spectrophotometric methods in the presence of its alkaline degradation products in its pure form and pharmaceutical dosage forms
  • Separate and measure cefoxitin sodium in commercial drug products by high-performance liquid chromatography (HPLC)

General description

Cefoxitin is a β-lactam that belongs to the group of cephamycin antibiotics and is considered a 2nd generation cephalosporin. It shows resistance to β-lactamases and is used to treat a broad spectrum of bacterial infections caused by gram-positive and gram-negative bacteria, such as bronchitis, pharyngitis, meningitis, and urinary tract infection among others. It is used for intravenous and intramuscular injections. It is found to be active against Bacteroides and is therapeutically used for the treatment of mixed aerobic-anaerobic infections.

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1B

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

涉药品监管产品
涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000466566
0000466566
0000438488
0000438488
0000444789

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Spectrofluorimetric analysis of cefoxitin in pharmaceutical dosage
Talanta, 41(4), 557-563 (1994)
Methicillin-resistant Staphylococcus aureus screening by online immunometric monitoring of bacterial growth under selective pressure.
Stenholm T, et al.
Antimicrobial Agents and Chemotherapy, 53(12), 5088-5094 (2009)
Antibiotic and chemotherapy e-book, 14(3), 257-266 (2010)
Analysis of binary mixtures of cephalothin and cefoxitin by using first-derivative spectrophotometry
Murillo.A.J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 14(3), 257-266 (1996)
Olga Snitser et al.
Nature communications, 11(1), 6038-6038 (2020-11-29)
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is threatening public health as it spreads worldwide across diverse environments. Its genetic hallmark, the mecA gene, confers resistance to many β-lactam antibiotics. Here, we show that, in addition, mecA provides a broad selective advantage
View All Related Papers

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Product Information Sheet - C4786

Product Information Sheet

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