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C4786

Cefoxitin sodium salt

Name: Cefoxitin sodium salt
Brand: SIAL

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₆N₃NaO₇S₂

CAS Number:

33564-30-6

Molecular Weight:

449.43

NACRES:

NA.24

PubChem Substance ID:

329775070

UNSPSC Code:

41116107

EC Number:

251-574-6

MDL number:

MFCD00079042

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form

powder or granules

Quality Level

200

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

storage temp.

2-8°C

SMILES string

[Na+].CO[C@]2(NC(=O)Cc1cccs1)C3SCC(COC(N)=O)=C(N3C2=O)C([O-])=O

InChI

1S/C16H17N3O7S2.Na/c1-25-16(18-10(20)5-9-3-2-4-27-9)13(23)19-11(12(21)22)8(6-26-15(17)24)7-28-14(16)19;/h2-4,14H,5-7H2,1H3,(H2,17,24)(H,18,20)(H,21,22);/q;+1/p-1/t14-,16+;/m1./s1

InChI key

GNWUOVJNSFPWDD-XMZRARIVSA-M

Related Categories

Analytical Chemistry

Analytical Chromatography

Chromatography Standards

Controlled Substances & Illicit Drug Standards

Reference Materials

General description

Cefoxitin is a β-lactam that belongs to the group of cephamycin antibiotics and is considered a 2^nd generation cephalosporin. It shows resistance to β-lactamases and is used to treat a broad spectrum of bacterial infections caused by gram-positive and gram-negative bacteria, such as bronchitis, pharyngitis, meningitis, and urinary tract infection among others. It is used for intravenous and intramuscular injections. It is found to be active against Bacteroides and is therapeutically used for the treatment of mixed aerobic-anaerobic infections.

Application

The analytical standard can be used to:

Determine cefoxitin sodium using four stability-indicating spectrophotometric methods in the presence of its alkaline degradation products in its pure form and pharmaceutical dosage forms
Separate and measure cefoxitin sodium in commercial drug products by high-performance liquid chromatography (HPLC)

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1B

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

涉药品监管产品

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Spectrofluorimetric analysis of cefoxitin in pharmaceutical dosage

Talanta, 41(4), 557-563 (1994)

Methicillin-resistant Staphylococcus aureus screening by online immunometric monitoring of bacterial growth under selective pressure.

Stenholm T, et al.

Antimicrobial Agents and Chemotherapy, 53(12), 5088-5094 (2009)

Antibiotic and chemotherapy e-book, 14(3), 257-266 (2010)

Rapid detection, differentiation and typing of methicillin-resistant Staphylococcus aureus harbouring either mecA or the new mecA homologue mecA(LGA251).

M Stegger et al.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(4), 395-400 (2012-03-21)

The recent finding of a new mecA homologue, mecA(LGA251) , with only 70% nucleotide homology to the conventional mecA gene has brought the routine testing for mecA as a confirmatory test for methicillin-resistant Staphylococcus aureus (MRSA) into question. A multiplex

Cefoxitin as an alternative to carbapenems in a murine model of urinary tract infection due to Escherichia coli harboring CTX-M-15-type extended-spectrum β-lactamase.

Raphaël Lepeule et al.

Antimicrobial agents and chemotherapy, 56(3), 1376-1381 (2012-01-05)

We investigated the efficiency of the cephamycin cefoxitin as an alternative to carbapenems for the treatment of urinary tract infections (UTIs) due to Escherichia coli producing CTX-M-type extended-spectrum β-lactamases. The susceptible, UTI-inducing E. coli CFT073-RR strain and its transconjugant CFT073-RR

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Global Trade Item Number

SKU	GTIN
C4786-5G	04061833492918
C4786-250MG	04061833492901
C4786-1G	04061833492895

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