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CN34851

Supelco

Acetonitrile

≥99.90% (GC), gradient grade, suitable for HPLC

Synonym(s):

ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide

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About This Item

Linear Formula:
CH3CN
CAS Number:
75-05-8
Molecular Weight:
41.05
Beilstein:
741857
EC Number:
200-835-2
MDL number:
MFCD00001878
UNSPSC Code:
12352200
PubChem Substance ID:
329798431
grade:
gradient grade
technique(s):
HPLC: suitable
bp:
81-82 °C (lit.)
vapor pressure:
72.8 mmHg ( 20 °C)

Product Name

Acetonitrile, suitable for HPLC, gradient grade, ≥99.90% (GC)

grade

gradient grade

vapor density

1.41 (vs air)

vapor pressure

72.8 mmHg ( 20 °C)

Assay

≥99.90% (GC)

form

liquid

autoignition temp.

973 °F

expl. lim.

16 %

baseline drift measuring range

≤15 mAU (210 nm)

technique(s)

HPLC: suitable

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General description

Acetonitrile (MeCN), an aliphatic nitrile, is a colorless liquid with a pleasant odor. It is widely used as a solvent and intermediate in organic syntheses.[1] It is transparent to UV-visible light, making it highly applicable in spectrophotometric and fluorimetric techniques. As MeCN has low viscosity, high elution strength and is highly miscible in water, it is utilized as a mobile phase component in many chromatographic techniques. It also plays a major role as an extractant medium in liquid-liquid extraction, solid-phase extraction or microextraction.[2] Its infrared spectrum has been recorded.[3] Synthesis of alkyl hydroperoxides in MeCN by alkane oxidation with hydrogen peroxide in the presence of iron complexes has been studied.[4] The hydrogenation of MeCN to form ethylamine using Co-B amorphous alloy catalyst has been investigated.[5]

Application

Acetonitrile may be used as solvent in the following processes:
  • Determination of pKa values of organic superbases using the isodensity polarization continuum model (IPCM).[6]
  • Preparation of 1,2-azidoalcohols and 1,2-azidoamines via cerium(III) chloride assisted ring opening of epoxides and aziridines by sodium azide.[7]
  • Synthesis of cyano-bearing indolinones by oxidative arylalkylation of olefins in the presence of palladium catalyst.[8]
  • To study the dynamics of the intramolecular charge-transfer (ICT) reaction of 4-(dimethylamino)benzonitrile.[9]

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Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

35.6 °F - closed cup

Flash Point(C)

2.0 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
S93031
S93271
S92771
S92671
S92150

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