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Merck
CN

CN50940

Guanidine hydrochloride

≥99.5%

Synonym(s):

Guanidine hydrochloride, Aminoformamidine hydrochloride, Aminomethanamidine hydrochloride, Guanidinium chloride

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About This Item

Linear Formula:
NH2C(=NH)NH2 · HCl
CAS Number:
50-01-1
Molecular Weight:
95.53
UNSPSC Code:
12352107
PubChem Substance ID:
329757653
NACRES:
NA.23
Beilstein/REAXYS Number:
3591990
MDL number:
MFCD00013026

Key Documents

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SMILES string

Cl[H].NC(N)=N, Cl[H].NC(N)=N

InChI

1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H, 1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H

InChI key

PJJJBBJSCAKJQF-UHFFFAOYSA-N, PJJJBBJSCAKJQF-UHFFFAOYSA-N

form

powder (or crystals)

mp

180-185 °C (lit.)

density

1.3 g/cm3 (lit.)

storage temp.

room temp

Quality Level

200

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General description

Guanidine hydrochloride is widely used in molecular biology and protein processing, with key roles in protein denaturation, nucleic acid extraction, and protein refolding.

Application

For IVD application, for protein analysis
Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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