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Merck
CN

D007

Supelco

R(−)-Chloroethylnorapomorphine hydrochloride

analytical standard

Synonym(s):

NCA hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C18H18ClNO2 · HCl
CAS Number:
75344-87-5
Molecular Weight:
352.25
MDL number:
MFCD00069237
UNSPSC Code:
41116107
PubChem Substance ID:
329798579
NACRES:
NA.24

Key Documents

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grade

analytical standard

Quality Level

100

Assay

≥85%

form

solid

storage condition

desiccated
protect from light

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

off-white

solubility

0.1 M HCl: soluble
H2O: soluble
aqueous base: unstable

format

neat

storage temp.

2-8°C

SMILES string

Cl.Oc1ccc2C[C@H]3N(CCCl)CCc4cccc(c34)-c2c1O

InChI

1S/C18H18ClNO2.ClH/c19-7-9-20-8-6-11-2-1-3-13-16(11)14(20)10-12-4-5-15(21)18(22)17(12)13;/h1-5,14,21-22H,6-10H2;1H/t14-;/m1./s1

InChI key

ASPGECRWCJCPPO-PFEQFJNWSA-N

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Irreversible dopamine receptor alkylating agent

Preparation Note

Dissolve in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidants. Solutions should be freshly prepared.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H336

Hazard Classifications

STOT SE 3

Target Organs

Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
FN04182017
FN02172220

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G J Kilpatrick et al.
European journal of pharmacology, 107(1), 71-78 (1984-12-15)
N-(chloroethyl)-norapomorphine (NCA) irreversibly inhibits striatal dopamine function, the binding of dopamine agonist ligands and dopamine-stimulated adenylate cyclase. A selective interaction of [3H]NCA with dopamine receptor sites would be of use in the characterisation and isolation of brain dopamine receptors. In
J Lehmann et al.
European journal of pharmacology, 90(4), 393-400 (1983-06-17)
(-)-N-(2-Chloroethyl)-norapomorphine [-)-NCA) inhibited in a concentration-dependent manner the electrically evoked [3H]acetylcholine release in slices of cat caudate. The inhibition by (-)-NCA was reversible and antagonized by the benzamide neuroleptic S-sulpiride. Although (-)-NCA is an irreversible antagonist at some behaviorally relevant
M Schmidt et al.
European journal of pharmacology, 97(1-2), 75-85 (1984-01-13)
The renal vascular effects of aporphines and related compounds were studied on the isolated perfused rat kidney in the presence of 10(-5) M phenoxybenzamine and 10(-5) M sotalol and after contraction of the vascular bed with prostaglandin F2 alpha (10(-7)
The effects of (-)N-(chloroethyl)-norapomorphine on [3H]-apomorphine binding to striatal dopamine receptors.
M W Goosey et al.
Biochemical pharmacology, 31(22), 3693-3694 (1982-11-15)
M Williams et al.
European journal of pharmacology, 91(2-3), 235-238 (1983-07-22)
NCA, the chloro analog of the potent dopamine agonist NPA is an irreversible ligand at dopamine receptors in mammalian brain. The chloroethyl analog of the recently described putative dopamine autoreceptor agonist 3-PPP, 3-PPP-C1, was evaluated for its potential use as
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