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D125806

N,N-Diisopropylethylamine

Name: <I>N</I>,<I>N</I>-Diisopropylethylamine
Brand: SIAL

≥99%, liquid, ReagentPlus^®

Synonym(s):

N-Ethyldiisopropylamine, DIPEA, Ethyldiisopropylamine, Hünig’s base

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About This Item

Linear Formula:

[(CH₃)₂CH]₂NC₂H₅

CAS Number:

7087-68-5

Molecular Weight:

129.24

NACRES:

NA.21

PubChem Substance ID:

329798682

UNSPSC Code:

12352100

EC Number:

230-392-0

MDL number:

MFCD00008868

Assay:

≥99%

Form:

liquid

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Properties

Product Name

N,N-Diisopropylethylamine, ReagentPlus^®, ≥99%

vapor pressure

31 mmHg ( 37.7 °C)

Quality Level

200

product line

ReagentPlus^®

assay

≥99%

form

liquid

refractive index

n20/D 1.414 (lit.)

bp

127 °C (lit.)

mp

<−50 °C (lit.)

density

0.742 g/mL at 25 °C (lit.)

SMILES string

CCN(C(C)C)C(C)C

InChI

1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3

InChI key

JGFZNNIVVJXRND-UHFFFAOYSA-N

Description

General description

N,N-Diisopropylethylamine, also known as Hünig′s base, is a sterically hindered amine. It is a non-nucleophilic base commonly employed for substitution reactions. It acts as an activator for chiral iridium N, P ligand complexes, which can be utilized in the hydrogenation of α, β-unsaturated nitriles. The influence of varying concentration of N,N-diisopropylethylamine on the synthesis of olvanil in the presence of lipase catalyst has been investigated.

Application

Proton scavenger used in peptide coupling, enolboration, Pd(0)-catalyzed alkoxycarbonylation of allyl phosphates and acetates, and as a catalyst in vinyl sulfone synthesis.

N,N-Diisopropylethylamine may be used in the synthesis of mannosylated ovalbumin peptides.