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D2600000

Diphenhydramine hydrochloride

Name: Diphenhydramine hydrochloride
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):

2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride

Empirical Formula (Hill Notation):

C₁₇H₂₁NO · HCl

CAS Number:

147-24-0

Molecular Weight:

291.82

MDL number:

MFCD00012479

PubChem Substance ID:

329798746

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

diphenhydramine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cl[H].CN(C)CCOC(c1ccccc1)c2ccccc2

InChI

1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H

InChI key

PCHPORCSPXIHLZ-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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Analytical Reference Standards

Sigma-Aldrich

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Diphenhydramine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Acetaminophen/diphenhydramine overdose in profound hypothermia.

A D Rollstin et al.

Clinical toxicology (Philadelphia, Pa.), 51(1), 50-53 (2012-12-01)

There are few reports of acetaminophen overdose in hypothermic patients and even fewer reports describing profound hypothermia. The kinetics, risk of hepatotoxicity, and the possible dose adjustments to N-acetylcysteine (NAC) therapy are not known in this setting. A 37-year-old female

The antihistamine diphenhydramine is extremely persistent in agricultural soil.

Edward Topp et al.

The Science of the total environment, 439, 136-140 (2012-10-16)

The widely used antihistamine diphenhydramine is present in municipal biosolids, and is detected in runoff from agricultural land fertilized with biosolids. In the present study the kinetics and major pathways of diphenhydramine dissipation in a loam, sandy loam, and clay

Changing patterns of drug and alcohol use in fatally injured drivers in Washington State.

Eugene W Schwilke et al.

Journal of forensic sciences, 51(5), 1191-1198 (2006-10-05)

We have previously reported on patterns of drug and alcohol use in fatally injured drivers in Washington State. Here we revisit that population to examine how drug use patterns have changed in the intervening 9 years. Blood and serum specimens

Human genome-guided identification of memory-modulating drugs.

Andreas Papassotiropoulos et al.

Proceedings of the National Academy of Sciences of the United States of America, 110(46), E4369-E4374 (2013-10-23)

In the last decade there has been an exponential increase in knowledge about the genetic basis of complex human traits, including neuropsychiatric disorders. It is not clear, however, to what extent this knowledge can be used as a starting point

Valproic acid reduces the tolerability of temsirolimus in children and adolescents with solid tumors.

Don W Coulter et al.

Anti-cancer drugs, 24(4), 415-421 (2013-01-19)

A pediatric study has established a maximum tolerated dose (MTD) for temsirolimus (Tem) of more than 150 mg/m intravenously/week. A phase I trial was conducted to establish the MTD for Tem in combination with valproic acid (VPA) in children and

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