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D2920000

Disopyramide

Name: Disopyramide
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

α-Diisopropylaminoethyl-α-phenylpyridine-2-acetamide

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₉N₃O

CAS Number:

3737-09-5

Molecular Weight:

339.47

NACRES:

NA.24

PubChem Substance ID:

329798759

UNSPSC Code:

41116107

MDL number:

MFCD00057366

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Properties

grade

pharmaceutical primary standard

API family

disopyramide

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC(C)N(CCC(C(N)=O)(c1ccccc1)c2ccccn2)C(C)C

InChI

1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25)

InChI key

UVTNFZQICZKOEM-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Disopyramide EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Class IA antiarrhythmic; sodium channel blocker

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H361fd

pcodes

P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Effect of disopyramide on left ventricular pressure gradient in hypertrophic obstructive cardiomyopathy in comparison with propranolol--a case report.

T Tokudome et al.

Angiology, 50(4), 331-335 (1999-05-04)

The effect of intravenous administration of disopyramide (total dose 100 mg, bolus 20 mg every 5 minutes) was compared with that of propranolol (total dose 10 mg, bolus 2 mg every 5 minutes) in a patient with hypertrophic obstructive cardiomyopathy.

[Comparison of the efficacy of moricizine and disopyramide in the treatment of ventricular extrasystoles].

J P Fauchier et al.

Archives des maladies du coeur et des vaisseaux, 84(4), 553-560 (1991-04-01)

Moricizine chlorhydrate (Ethmozine), a relatively unknown antiarrhythmic agent in France, is a derivative of Phenothiazine, related to the Vaughan-Williams Class IB drugs. A randomised, double-blind, crossover trial with Disopyramide 600 mg/day after a placebo period in 10 patients with ventricular

Procainamide and disopyramide.

C Ribeiro et al.

European heart journal, 8 Suppl A, 11-19 (1987-03-01)

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Global Trade Item Number

SKU	GTIN
D2920000	04061833562703