D4285
(±)-Dropropizine
analytical standard, for drug analysis
Synonym(s):
3-(4-Phenyl-1-piperazinyl)-1,2-propanediol
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About This Item
Empirical Formula (Hill Notation):
C13H20N2O2
CAS Number:
Molecular Weight:
236.31
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
241-683-7
MDL number:
InChI
1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2
InChI key
PTVWPYVOOKLBCG-UHFFFAOYSA-N
SMILES string
OCC(O)CN1CCN(CC1)c2ccccc2
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
Quality Level
General description
(±)-Dropropizine is an antitussive therapeutic agent that inhibits cough through the peripheral mode of action.
Application
(±)-Dropropizine may be used as a reference standard for the determination of (±)-dropropizine in pharmaceutical formulations by spectrophotometric method.
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Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms.
Abdallah, O M.
International Journal of Analytical Chemistry (2010)
A Lavezzo et al.
Pulmonary pharmacology, 5(2), 143-147 (1992-06-01)
The mechanism of action of levodropropizine has been investigated in different models of experimentally-induced cough in guinea-pigs. In particular it has been demonstrated that the antitussive drug has a peripheral site of action by injecting the drug intracerebroventricularly (i.c.v.). In
Novel route for the resolution of both enantiomers of dropropizine by using oxime esters and supported lipases of Pseudomonas cepacia.
Salunkhe M M, et al.
Enzyme and Microbial Technology, 28(4-5), 333-338 (2001)
H Shams et al.
British journal of pharmacology, 117(5), 853-858 (1996-03-01)
1. Levodropropizine (LVDP) is an effective antitussive drug. Its effects on single-unit discharge of vagal afferent C-fibres were tested in anaesthetized cats to assess whether an inhibition of vagal C-fibres is involved in its antitussive properties. Vagal C-fibres, identified by
Francesco De Blasio et al.
Pulmonary pharmacology & therapeutics, 25(5), 337-342 (2012-07-10)
Cough in children is among the most common problems managed by pediatricians, and occurs more frequently in preschool than in older children. Most acute episodes of cough are due to viral upper respiratory tract infections. The morbidity associated with acute
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