D4285
(±)-Dropropizine
analytical standard, for drug analysis
Synonym(s):
3-(4-Phenyl-1-piperazinyl)-1,2-propanediol
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About This Item
Empirical Formula (Hill Notation):
C13H20N2O2
CAS Number:
Molecular Weight:
236.31
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
241-683-7
MDL number:
Quality Segment
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
SMILES string
OCC(O)CN1CCN(CC1)c2ccccc2
InChI
1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2
InChI key
PTVWPYVOOKLBCG-UHFFFAOYSA-N
General description
(±)-Dropropizine is an antitussive therapeutic agent that inhibits cough through the peripheral mode of action.
Application
(±)-Dropropizine may be used as a reference standard for the determination of (±)-dropropizine in pharmaceutical formulations by spectrophotometric method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
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Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms.
Abdallah, O M.
International Journal of Analytical Chemistry (2010)
A Lavezzo et al.
Pulmonary pharmacology, 5(2), 143-147 (1992-06-01)
The mechanism of action of levodropropizine has been investigated in different models of experimentally-induced cough in guinea-pigs. In particular it has been demonstrated that the antitussive drug has a peripheral site of action by injecting the drug intracerebroventricularly (i.c.v.). In
H Shams et al.
British journal of pharmacology, 117(5), 853-858 (1996-03-01)
1. Levodropropizine (LVDP) is an effective antitussive drug. Its effects on single-unit discharge of vagal afferent C-fibres were tested in anaesthetized cats to assess whether an inhibition of vagal C-fibres is involved in its antitussive properties. Vagal C-fibres, identified by