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Merck
CN

D4285

Supelco

(±)-Dropropizine

analytical standard, for drug analysis

Synonym(s):

3-(4-Phenyl-1-piperazinyl)-1,2-propanediol

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About This Item

Empirical Formula (Hill Notation):
C13H20N2O2
CAS Number:
17692-31-8
Molecular Weight:
236.31
EC Number:
241-683-7
MDL number:
MFCD00079124
UNSPSC Code:
41116107
PubChem Substance ID:
329798797
NACRES:
NA.24

Key Documents

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Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

OCC(O)CN1CCN(CC1)c2ccccc2

InChI

1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2

InChI key

PTVWPYVOOKLBCG-UHFFFAOYSA-N

General description

(±)-Dropropizine is an antitussive therapeutic agent that inhibits cough through the peripheral mode of action.

Application

(±)-Dropropizine may be used as a reference standard for the determination of (±)-dropropizine in pharmaceutical formulations by spectrophotometric method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

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Novel route for the resolution of both enantiomers of dropropizine by using oxime esters and supported lipases of Pseudomonas cepacia.
Salunkhe M M, et al.
Enzyme and Microbial Technology, 28(4-5), 333-338 (2001)
A Lavezzo et al.
Pulmonary pharmacology, 5(2), 143-147 (1992-06-01)
The mechanism of action of levodropropizine has been investigated in different models of experimentally-induced cough in guinea-pigs. In particular it has been demonstrated that the antitussive drug has a peripheral site of action by injecting the drug intracerebroventricularly (i.c.v.). In
Sensitive spectrophotometric method for quantitation of guaifenesin and dropropizine in their dosage forms.
Abdallah, O M.
International Journal of Analytical Chemistry (2010)
M Sutovska et al.
Bratislavske lekarske listy, 110(5), 269-275 (2009-06-11)
The ATP-sensitive potassium ion channels (K+ATP) are widely expressed on airway sensory nerves that mediate cough and other protective reflexes; dependent on airways smooth muscles (ASM) reactivity. The study was conducted to determine the involvement of K+ATP in airway sensory
P L Munt et al.
Arzneimittel-Forschung, 44(2), 153-155 (1994-02-01)
The antitussive activity of levodropropizine (S(-)3-(4-phenyl-piperazine-1-yl)-propane-1,2-diol, DF 526, CAS 99291-25-5) was evaluated after oral administration to the conscious dog. Levodropropizine had a good antitussive activity, comparable with, but having a longer duration of action than dropropizine, the racemate from which
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