D8890
Dipyrone
analytical standard
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About This Item
Linear Formula:
C13H16N3O4SNa
CAS Number:
Molecular Weight:
333.34
UNSPSC Code:
41116107
PubChem Substance ID:
EC Number:
200-694-7
MDL number:
SMILES string
[Na].CN(CS(O)(=O)=O)C1=C(C)N(C)N(C1=O)c2ccccc2
grade
analytical standard
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
veterinary
format
neat
storage temp.
2-8°C
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
A non-steroidal anti-inflammatory drug that, when coadministered with morphine, potentiates its antinociceptive action and delays the development of tolerance. Dipyrone is a relatively selective inhibitor of cyclooxygenase-3 (COX-3), with lower activity against COX-1 and no activity against COX-2. Blocks PGE2-induced hyperalgesia in several models.
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Regulatory Information
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Jayne Edwards et al.
The Cochrane database of systematic reviews, (9)(9), CD003227-CD003227 (2010-09-09)
Dipyrone (metamizole) is a non-steroidal anti-inflammatory drug used in some countries to treat pain (postoperative, colic, cancer, and migraine); it is banned in others because of an association with life-threatening blood agranulocytosis. This review updates a 2001 Cochrane review, and
Luiz Henrique Agra Cavalcante-Silva et al.
Marine drugs, 10(9), 1977-1992 (2012-11-03)
The marine environment is an extraordinary reservoir of bioactive natural products, many of which exhibit chemical and structural features not found in terrestrial natural products. In this regard, the aim of this study was to investigate the possible antinociceptive and
M Levy et al.
Clinical pharmacokinetics, 28(3), 216-234 (1995-03-01)
The pharmacokinetics of dipyrone are characterised by rapid hydrolysis to the active moiety 4-methyl-amino-antipyrine (MAA), which has 85% bioavailability after oral administration in tablet form, and takes a short time to achieve maximal systemic concentrations (tmax of 1.2 to 2.0
María Francisco et al.
Pancreas, 41(8), 1325-1330 (2012-06-23)
This study aimed to describe the mode of refeeding, frequency of intolerance, and related factors in mild acute pancreatitis (AP). We included all cases of mild AP between January 2007 and December 2009 in an observational, descriptive, and retrospective study.
Luis Alfonso Moreno-Rocha et al.
Pharmacology, biochemistry, and behavior, 103(1), 1-5 (2012-08-08)
Combinations of two analgesic drugs of the same or different class are widely used in clinical therapy to enhance its antinociceptive effects and reduce the side effects. In order to evaluate a possible antinociceptive synergistic interaction of metamizol s.c., a
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