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Merck
CN

H0325000

Hexetidine

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Hexetidine, mixture of stereoisomers, 5-Amino-1,3-bis(2-ethylhexyl)hexahydro-5-methylpyrimidine, NSC 17764

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About This Item

Empirical Formula (Hill Notation):
C21H45N3
CAS Number:
141-94-6
Molecular Weight:
339.60
NACRES:
NA.24
PubChem Substance ID:
329815112
UNSPSC Code:
41116107
MDL number:
MFCD00010428

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InChI

1S/C21H45N3/c1-6-10-12-19(8-3)14-23-16-21(5,22)17-24(18-23)15-20(9-4)13-11-7-2/h19-20H,6-18,22H2,1-5H3

SMILES string

CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1

InChI key

DTOUUUZOYKYHEP-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

hexetidine

manufacturer/tradename

EDQM

refractive index

n20/D 1.4649 (lit.)

bp

160 °C/0.4 mmHg (lit.)

density

0.889 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Related Categories

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Involved in studies:
  • To identify pure liquid salt forms of aspirin
  • Of alkyl based selective displacers for protein purification via ion exchange chromatography
  • Of the in vivo application of models for testing drugs against nonreplicating Mycobacterium tuberculosis
  • Nutrient-sensitized screening for drugs that shift the energy metabolism from mitochondrial respiration to glycolysis
  • Inhibition of angiogensis
  • Screening antimalarial drugs

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

158.0 °F - closed cup

flash_point_c

70 °C - closed cup

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Certificates of Analysis (COA)

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Elvedina Kapić et al.
Medicinski arhiv, 56(1), 43-48 (2002-03-29)
Hexetidine is very safe oral antiseptic with broad antibacterial and antifungal activity in vivo and in vitro. It has local-anesthetics, astringent and deodorant activity. Also, it has very strong antiplac effects. Resistention of microorganisms on hexetidine is short and transient.
F Afennich et al.
International journal of dental hygiene, 9(3), 182-190 (2011-03-02)
To review the literature concerning hexetidine-containing mouthwash as a monotherapy or as an adjunct to oral hygiene in the prevention of plaque accumulation and gingival inflammation. PubMed-MEDLINE and the Cochrane-CENTRAL were searched through January 2010 to identify appropriate studies. The
Andreas Peyrl et al.
Journal of neuro-oncology, 120(1), 139-145 (2014-07-16)
The Ommaya reservoir facilitates repetitive delivery of drugs into the CSF and is a pharmacologically rational system for intrathecal chemotherapy. Because previous studies have found a high rate of infection and other complications we herein studied our experience with this
Synergistic antiplaque effects of a zinc fluoride/hexetidine containing mouthwash. A review.
U P Saxer et al.
Schweizerische Monatsschrift fur Zahnheilkunde = Revue mensuelle suisse d'odonto-stomatologie, 93(8), 689-704 (1983-08-01)

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