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Merck
CN

H102

Supelco

Haloperidol metabolite II

analytical standard

Synonym(s):

(±)-4-(4-Chlorophenyl)-α-(4-fluorophenyl)-4-hydroxy-1-piperidinebutanol, Reduced Haloperidol

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About This Item

Empirical Formula (Hill Notation):
C21H25ClFNO2
CAS Number:
34104-67-1
Molecular Weight:
377.88
MDL number:
MFCD00055102
UNSPSC Code:
41116107
PubChem Substance ID:
329815151
NACRES:
NA.24

Key Documents

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grade

analytical standard

Quality Level

100

Assay

≥98% (HPLC)

form

solid

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white

solubility

DMSO: 10 mg/mL

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

OC(CCCN1CCC(O)(CC1)c2ccc(Cl)cc2)c3ccc(F)cc3

InChI

1S/C21H25ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,20,25-26H,1-2,11-15H2

InChI key

WNZBBTJFOIOEMP-UHFFFAOYSA-N

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
FN09271904
0000380057
0000465213
0000465213
0000380057

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Naoya Kishikawa et al.
Analytical and bioanalytical chemistry, 386(3), 719-724 (2006-09-08)
A simultaneous method for the determination of haloperidol (HP) and its metabolite, reduced haloperidol (RHP), in human serum was developed by means of high-performance liquid chromatography (HPLC) with fluorescence detection. Suzuki coupling reaction with a fluorescent arylboronic acid, 4-(4,5-diphenyl-1H-imidazol-2-yl)phenylboronic acid
W H Chang et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 4(2), 119-126 (1994-06-01)
Plasma haloperidol (HL) and reduced haloperidol (RH) levels were measured in 60 schizophrenic patients treated with high to very high HL doses of 40-200 mg/day. Plasma samples were obtained at steady-state conditions and 10-12 h after the evening dose and
D W Eyles et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 8(2), 127-129 (1998-06-10)
In vitro, cytosolic human ketone reductases catalyse the stereospecific (i.e. >99%) formation of S(-) reduced haloperidol (RHP) from haloperidol (HP). Whether this situation is reflected in patients taking the drug is unknown. In this study in nine patients taking HP
L Pan et al.
European journal of clinical pharmacology, 55(8), 599-604 (1999-12-14)
To investigate in vitro which CYP isoforms (CYP1A2, CYP2D6 and CYP3A4) are involved in the biotransformation of haloperidol (HAL) and reduced haloperidol (RHAL). The biotransformation of HAL and RHAL is evaluated by measuring HAL and RHAL remaining after incubation with
J G Shin et al.
British journal of clinical pharmacology, 51(1), 45-52 (2001-02-13)
We evaluated the inhibitory effect of haloperidol and its metabolites on CYP2D6 activity in order to better understand the potential role of these metabolites in drug interactions involving haloperidol. The inhibitory effects of haloperidol and five of its metabolites on
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