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Merck
CN

M0120010

Malathion impurity B

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Malaoxon, Diethyl 2-[(dimethoxyphosphoryl)sulfanyl]succinate

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About This Item

Empirical Formula (Hill Notation):
C10H19O7PS
CAS Number:
1634-78-2
Molecular Weight:
314.29
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329817728
MDL number:
MFCD00055461
Beilstein/REAXYS Number:
1804523

Key Documents

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Product Name

Malathion impurity B, European Pharmacopoeia (EP) Reference Standard

InChI key

WSORODGWGUUOBO-UHFFFAOYSA-N

SMILES string

CCOC(=O)CC(SP(=O)(OC)OC)C(=O)OCC

InChI

1S/C10H19O7PS/c1-5-16-9(11)7-8(10(12)17-6-2)19-18(13,14-3)15-4/h8H,5-7H2,1-4H3

grade

pharmaceutical primary standard

API family

malathion

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

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Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Application

Malathion impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

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Danger

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 3 Oral - Aquatic Chronic 2 - Carc. 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

>212.0 °F - closed cup

flash_point_c

> 100 °C - closed cup

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Baljinder Singh et al.
Biotechnology letters, 34(5), 863-867 (2012-04-06)
An axenic bacterial strain, Lysinibacillus sp. KB1, was isolated from malathion-contaminated soil. It tolerated malathion up to 0.15 % and, under aerobic conditions, utilized it as sole carbon source. 20 % malathion and 47 % malaoxon were degraded out of the initially provided
Rafael C Lajmanovich et al.
Ecotoxicology and environmental safety, 73(7), 1517-1524 (2010-08-17)
Soybean fields provide habitats for many species of amphibians. However, the persistence and health of amphibian populations may be at risk from the increasing use of pesticides and other agricultural chemicals. We examined the activities of acetylcholinesterase (AChE), butyrylcholinesterase (BChE)
Agustín Basso et al.
Environmental science and pollution research international, 19(1), 214-225 (2011-07-01)
In this study, we determined normal serum butyrylcholinesterase (BChE) and carboxylesterase (CbE) activities in Tupinambis merianae in order to obtain reference values for organophosphorus pesticide monitoring. Forty-two T. merianae individuals were grouped by sex and size to identify potential differences
Timo Wille et al.
Chemico-biological interactions, 190(2-3), 79-83 (2011-03-01)
The simultaneous use of the repellent DEET, pyridostigmine, and organophosphorus pesticides has been assumed as a potential cause for the Gulf War Illness and combinations have been tested in different animal models. However, human in vitro data on interactions of
Winfred G Aker et al.
Environmental toxicology, 23(4), 548-554 (2008-02-06)
Malathion inhibits the critical body enzyme, acetylcholinesterase (AChE). This capability requires that malathion should first be converted to malaoxon to become an active anticholinesterase agent. Conversion can be caused by oxidation in mammals, insects, plants, and in sunlight. In this
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