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Merck
CN

M3157

Minaprine dihydrochloride

analytical standard

Synonym(s):

N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine

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About This Item

Empirical Formula (Hill Notation):
C17H22N4O · 2HCl
CAS Number:
25905-77-5
Molecular Weight:
371.30
NACRES:
NA.24
PubChem Substance ID:
329817964
UNSPSC Code:
41116107
EC Number:
247-329-8
MDL number:
MFCD00083410

Key Documents

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InChI key

GNUCGROXDZMCJI-UHFFFAOYSA-N

InChI

1S/C17H22N4O.2ClH/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21;;/h2-6,13H,7-12H2,1H3,(H,18,20);2*1H

SMILES string

Cl.Cl.Cc1cc(nnc1NCCN2CCOCC2)-c3ccccc3

grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Quality Level

200

Gene Information

human ... ACHE(43), CHRM1(1128), DRD2(1813), HTR2B(3357), HTR2C(3358), MAOA(4128), SLC6A4(6532)
rat ... Ache(83817), Camk2a(25400), Prkca(24680)

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Antidepressant

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

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Antidepressant response follows an exponential decay curve: replication and extension.
W Boyer
Journal of clinical psychopharmacology, 17(5), 426-427 (1997-10-08)
[Three cases of acute agranulocytosis: caused by minaprine?].
Y Bastion et al.
Presse medicale (Paris, France : 1983), 22(2), 82-83 (1993-01-23)
D Wheatley
The British journal of psychiatry : the journal of mental science, 161, 113-115 (1992-07-01)
Minaprine (200 mg daily, either once or divided b.d.) was compared with amitriptyline (25-50 mg t.d.s.) over six weeks in 144 patients with major depression. Significant reductions in HRSD scores at the end of six weeks' treatment were recorded with
R G Priest et al.
Journal of clinical psychopharmacology, 16(6), 420-424 (1996-12-01)
A very large number of therapeutic trials of antidepressant drugs have been reported in the scientific literature. Until now, the comparison of one drug with another, or with placebo, has been performed typically by comparing the scores on depression rating
J Jouglard et al.
Therapie, 51(5), 582-585 (1996-09-01)
By 1990, the Clin Midy (SANOFI) laboratory had modified the dose of Cantor tablets: the content of active drug (minaprine) increased (50 to 100 mg). Therefore, acute intoxication by minaprine can be serious, with generalized seizures, resisting the classic treatment.
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