M4627
1-Methylnicotinamide chloride
analytical standard
Synonym(s):
N-Methylnicotinic acid amide chloride
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About This Item
Linear Formula:
C7H9N2OCl
CAS Number:
Molecular Weight:
172.61
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
grade
analytical standard
Quality Level
assay
≥97.5%
form
powder
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
color
white
application(s)
forensics and toxicology
veterinary
vitamins, nutraceuticals, and natural products
format
neat
SMILES string
[Cl-].C[n+]1cccc(c1)C(N)=O
InChI
1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H
InChI key
BWVDQVQUNNBTLK-UHFFFAOYSA-N
General description
1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.
Application
1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Urinary excretion product of niacin metabolism
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Yoshitaka Tayama et al.
Drug metabolism and pharmacokinetics, 26(1), 94-101 (2010-11-19)
Aldehyde oxidase (AO) plays an important role in metabolizing antitumor and antiviral drugs, including methotrexate, cyclophosphamide and acyclovir. Green tea and its catechins have been shown to modulate the activities of various xenobiotic-metabolizing cytochrome P450 species, both in vivo and
Jacek Miedzobrodzki et al.
Acta poloniae pharmaceutica, 67(5), 487-494 (2010-09-30)
The study was designed to demonstrate the relationship between the activity of human normal monocytes and blood platelets, to determine the metabolic activity of normal monocytes and monocytes cooperating with blood platelets in respect of their generation of reactive oxygen
Quantitation of the niacin metabolites 1-methylnicotinamide and l-methyl-2-pyridone-5-carboxamide in random spot urine samples, by ion-pairing reverse-phase HPLC with UV detection, and the implications for the use of spot urine samples in the assessment of niacin status
Creeke IP, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 817, 247-253 (2005)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M4627-1G | 04061826762240 |