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Merck
CN

M4627

1-Methylnicotinamide chloride

analytical standard

Synonym(s):

N-Methylnicotinic acid amide chloride

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About This Item

Linear Formula:
C7H9N2OCl
CAS Number:
1005-24-9
Molecular Weight:
172.61
NACRES:
NA.24
PubChem Substance ID:
329817903
UNSPSC Code:
41116107
MDL number:
MFCD00060042

Key Documents

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Product Name

1-Methylnicotinamide chloride, analytical standard

InChI

1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H

SMILES string

[Cl-].C[n+]1cccc(c1)C(N)=O

InChI key

BWVDQVQUNNBTLK-UHFFFAOYSA-N

grade

analytical standard

assay

≥97.5%

form

powder

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white

application(s)

forensics and toxicology
veterinary
vitamins, nutraceuticals, and natural products

format

neat

Quality Level

100

Related Categories

Application

1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Urinary excretion product of niacin metabolism

General description

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000483819
0000483819
0000369166
0000369166
SLCR0536

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Robert Nowak et al.
European journal of pharmacology, 640(1-3), 102-111 (2010-05-08)
The aim of the study was to examine the effect of 1-methylnicotinamide (MNA) and 1-methyl-3-nitropyridine (MNP) on mitochondria activity and proliferation of endothelial EA.hy926 cells. The activity of MNA was also referred to nicotinamide (NAM) being MNA metabolic precursor. NAM
Shi-Sheng Zhou et al.
World journal of gastroenterology, 15(45), 5674-5684 (2009-12-05)
To investigate whether nicotinamide overload plays a role in type 2 diabetes. Nicotinamide metabolic patterns of 14 diabetic and 14 non-diabetic subjects were compared using HPLC. Cumulative effects of nicotinamide and N(1)-methylnicotinamide on glucose metabolism, plasma H(2)O(2) levels and tissue
M N Khodosovskiĭ et al.
Eksperimental'naia i klinicheskaia farmakologiia, 73(4), 11-13 (2010-05-22)
We have studied the effect of 1-methylnicotinamide (MNA) on prooxidant - antioxidant balance parameters by measuring the concentrations of lipid peroxidation products (conjugated dienes (CD) and Schiff bases (SB)) and antioxidant system factors (alpha-tocoferol (alpha-T), retinol (Ret) in the blood
Yoshitaka Tayama et al.
Drug metabolism and pharmacokinetics, 27(5), 543-547 (2012-03-29)
Aldehyde oxidase (AO) plays a role in metabolizing many drugs, such as methotrexate and 6-mercaptopurine. We previously showed that AO activity in rat liver rapidly increases from birth, reaching a plateau within 4 weeks, and is regulated at the protein
Stefan Chłopicki et al.
Pharmacological reports : PR, 64(2), 369-376 (2012-06-05)
Methylnicotinamide (MNA) displays vasoprotective activity, however, the regulation of the activity of nicotinamide-N-methyltransferase (NNMT), is largely unknown. We analyze a possible involvement of IL-6 in the activation of NNMT-MNA pathway during an endurance exercise. FVB, C57Bl/6J IL6(+/+) and C57Bl/6J IL-6(-/-)
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