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Merck
CN

M8402

Mefexamide hydrochloride

analytical standard, for drug analysis

Synonym(s):

p-Methoxyphenoxyacetic acid 2-(diethylamino)ethylamide

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About This Item

Empirical Formula (Hill Notation):
C15H24N2O3 · HCl
CAS Number:
1227-61-8
Molecular Weight:
316.82
NACRES:
NA.24
PubChem Substance ID:
329818058
UNSPSC Code:
41116107
EC Number:
214-963-1
MDL number:
MFCD00079457

Key Documents

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InChI key

AXBHPHPHZHAOAK-UHFFFAOYSA-N

InChI

1S/C15H24N2O3.ClH/c1-4-17(5-2)11-10-16-15(18)12-20-14-8-6-13(19-3)7-9-14;/h6-9H,4-5,10-12H2,1-3H3,(H,16,18);1H

SMILES string

Cl.CCN(CC)CCNC(=O)COc1ccc(OC)cc1

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

200

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

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W Gielsdorf et al.
Zeitschrift fur Rechtsmedizin. Journal of legal medicine, 87(4), 297-303 (1981-01-01)
After oral ingestion of 400 mg Mefexamidehydrochloride for Mefexamide (I) and its main degradation product Desmethyl-Mefexamide (II) the following pharmakokinetic parameters have been determined: 1. Elimination of I and II follows 1st order kinetics. 2. Biological half-life t 1/2 for
[Correction of psychodepressive effects of benzodiazepine tranquilizers by administration of psychostimulants].
Iu G Bobkov et al.
Biulleten' eksperimental'noi biologii i meditsiny, 94(10), 48-51 (1982-10-01)
W Gielsdorf
Zeitschrift fur Rechtsmedizin. Journal of legal medicine, 87(1-2), 117-127 (1981-01-01)
After oral administration of a therapeutic dosage (400 mg) Mefexamide (I), six excretion products were detected in human urine and subsequently identified by GC/MS and TLC: in addition to the unchanged drug (I) in the acidic extracted urine without hydrolysis
[Preliminary pharmacological investigations of six new p-chlorphenoxyacetic acid derivatives (author's transl)].
A Kruszewska et al.
Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina, 34, 259-268 (1979-01-01)

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