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N0020000

Nabumetone

Name: Nabumetone
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

4-(6-Methoxy-2-naphthyl)-2-butanone

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₆O₂

CAS Number:

42924-53-8

Molecular Weight:

228.29

NACRES:

NA.24

PubChem Substance ID:

329818390

UNSPSC Code:

41116107

MDL number:

MFCD00079518

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Properties

grade

pharmaceutical primary standard

API family

nabumetone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

COc1ccc2cc(CCC(C)=O)ccc2c1

InChI

1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3

InChI key

BLXXJMDCKKHMKV-UHFFFAOYSA-N

Gene Information

human ... PTGS2(5743)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Nabumetone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Nonselective non-steroidal anti-inflammatory drug (NSAID)

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients.

Jinhyun Kim et al.

Clinical therapeutics, 31(12), 2860-2872 (2010-01-30)

S-adenosylmethionine (SAMe) has antiinflammatory and analgesic effects and has been reported to ameliorate the pain and dysfunction of osteoarthritis (OA). The metabolism of SAMe can be affected by geographic or ethnic factors. However, its efficacy and tolerability versus NSAIDs have

Discovery of nonsteroidal anti-inflammatory drug and anticancer drug enhancing reprogramming and induced pluripotent stem cell generation.

Chao-Shun Yang et al.

Stem cells (Dayton, Ohio), 29(10), 1528-1536 (2011-09-08)

Recent breakthroughs in creating induced pluripotent stem cells (iPSCs) provide alternative means to obtain embryonic stem-like cells without destroying embryos by introducing four reprogramming factors (Oct3/4, Sox2, and Klf4/c-Myc or Nanog/Lin28) into somatic cells. iPSCs are versatile tools for investigating

Pseudoseptic arthritis due to acute lipoarthrosis in a systemic lupus erythematosus patient with osteonecrosis.

Robert W Ike et al.

Arthritis and rheumatism, 61(8), 1130-1132 (2009-08-01)

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Global Trade Item Number

SKU	GTIN
N0020000	04061833812952