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Merck
CN

N0392

Supelco

Nordoxepin hydrochloride

analytical standard, ≥98.0% (TLC), powder

Synonym(s):

11(6H)-(3-[Methylamino]propylidene)dibenz[b,e]oxepine

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About This Item

Empirical Formula (Hill Notation):
C18H19NO · HCl
CAS Number:
2887-91-4
Molecular Weight:
301.81
MDL number:
MFCD00135797
UNSPSC Code:
41116107
PubChem Substance ID:
329818430
NACRES:
NA.24

Key Documents

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grade

analytical standard

Quality Level

200

Assay

≥98.0% (TLC)

form

powder

technique(s)

HPLC: suitable

color

white to yellow

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

Cl.CNCC\C=C1/c2ccccc2COc3ccccc13

InChI

1S/C18H19NO.ClH/c1-19-12-6-10-16-15-8-3-2-7-14(15)13-20-18-11-5-4-9-17(16)18;/h2-5,7-11,19H,6,12-13H2,1H3;1H/b16-10+;

InChI key

GNPPEZGJRSOKRE-QFHYWFJHSA-N

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Doxepin metabolite.

Features and Benefits

Shelf-life of the powder is at least 10 years.

Other Notes

Mixture of cis- and trans-isomers

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000395826
0000395826
0000292639
0000236432
0000236432

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C W Harrell et al.
Electrophoresis, 19(5), 712-718 (1998-06-18)
The separation of seven structurally similar antidepressant drugs (amitriptyline, nortriptyline, imipramine, desipramine, protriptyline, doxepin, and nordoxepin) was achieved in under 15 min using a novel nonionic micelle polymer, poly(n-undecyl-alpha-D-glucopyranoside) (PUG) by use of capillary zone electrophoresis (CZE). Systematic studies with
H Ghabrial et al.
Drug metabolism and disposition: the biological fate of chemicals, 19(3), 596-599 (1991-05-01)
The N-demethylation of the individual Z-(cis) and E-(trans) isomers of the tricyclic antidepressant doxepin was studied by examining the 0-8 hr serum concentration-time and the 0-72 hr urinary excretion profiles of parent drug and metabolite in eight healthy males who
Kamal K Midha et al.
Pharmaceutical research, 21(8), 1331-1344 (2004-09-14)
The role of metabolites in bioequivalence studies has been a contentious issue for many years. Many papers have published recommendations for the use of metabolite data based on anecdotal evidence from the results of bioequivalence studies. Such anecdotal evidence has
Suryanarayana Sista et al.
Journal of clinical pharmacology, 43(10), 1149-1157 (2003-10-01)
A novel diltiazem HCl extended-release (ER) tablet formulation was developed for evening administration in the management of angina and hypertension. Pharmacokinetics of the formulation were evaluated to identify variations in morning (7 a.m. or 8 a.m.) versus evening (10 p.m.)
A Negrusz et al.
Journal of analytical toxicology, 22(6), 531-536 (1998-10-27)
Doxepin is a tricyclic antidepressant that is widely prescribed for the treatment of mild depression. In this study, hair samples collected from a patient receiving 25 mg of doxepin daily were analyzed. Doxepin was administered to the patient for 4
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