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Merck
CN

N0392

Nordoxepin hydrochloride

analytical standard, ≥98.0% (TLC), powder

Synonym(s):

11(6H)-(3-[Methylamino]propylidene)dibenz[b,e]oxepine

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About This Item

Empirical Formula (Hill Notation):
C18H19NO · HCl
CAS Number:
2887-91-4
Molecular Weight:
301.81
NACRES:
NA.24
PubChem Substance ID:
329818430
UNSPSC Code:
41116107
MDL number:
MFCD00135797

Key Documents

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InChI

1S/C18H19NO.ClH/c1-19-12-6-10-16-15-8-3-2-7-14(15)13-20-18-11-5-4-9-17(16)18;/h2-5,7-11,19H,6,12-13H2,1H3;1H/b16-10+;

SMILES string

Cl.CNCC\C=C1/c2ccccc2COc3ccccc13

InChI key

GNPPEZGJRSOKRE-QFHYWFJHSA-N

grade

analytical standard

assay

≥98.0% (TLC)

form

powder

technique(s)

HPLC: suitable

color

white to yellow

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Quality Level

200

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Doxepin metabolite.

Features and Benefits

Shelf-life of the powder is at least 10 years.

Other Notes

Mixture of cis- and trans-isomers

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000395826
0000395826
0000292639
0000236432
0000236432

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C W Harrell et al.
Electrophoresis, 19(5), 712-718 (1998-06-18)
The separation of seven structurally similar antidepressant drugs (amitriptyline, nortriptyline, imipramine, desipramine, protriptyline, doxepin, and nordoxepin) was achieved in under 15 min using a novel nonionic micelle polymer, poly(n-undecyl-alpha-D-glucopyranoside) (PUG) by use of capillary zone electrophoresis (CZE). Systematic studies with
P D Hrdina et al.
Therapeutic drug monitoring, 12(2), 129-133 (1990-03-01)
Plasma levels of doxepin and desmethyldoxepin were measured in split samples of 20 depressed patients treated with doxepin by using a conventional extraction and gas chromatography method on a packed column (method 1) and derivation of secondary amine and gas
Mei Zhang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(27), 3025-3030 (2009-08-04)
Perhexiline is a drug that is used for treatment of moderate to severe angina pectoris that has not responded to other treatment. It has a low therapeutic index, and saturable metabolism that is also subject to genetic polymorphism (CYP2D6). Concentration
C Dilger et al.
Arzneimittel-Forschung, 38(10), 1525-1528 (1988-10-01)
An improved high performance liquid chromatographic (HPLC) assay for the quantitative determination of trans-doxepin (I) and desmethyldoxepin (II) in body fluids is presented. This HPLC assay, employing a UV-detector and perazine (III) as an internal standard, provides a very sensitive
A Negrusz et al.
Journal of analytical toxicology, 22(6), 531-536 (1998-10-27)
Doxepin is a tricyclic antidepressant that is widely prescribed for the treatment of mild depression. In this study, hair samples collected from a patient receiving 25 mg of doxepin daily were analyzed. Doxepin was administered to the patient for 4
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