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N1230000

Norfloxacin

Name: Norfloxacin
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):

1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-3-quinolinecarboxylic acid

Empirical Formula (Hill Notation):

C₁₆H₁₈FN₃O₃

CAS Number:

70458-96-7

Molecular Weight:

319.33

MDL number:

MFCD00079532

PubChem Substance ID:

329818530

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

norfloxacin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCNCC3

InChI

1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)

InChI key

OGJPXUAPXNRGGI-UHFFFAOYSA-N

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Analytical Reference Standards

Pharmacopeia & Metrological Institute Standards

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Norfloxacin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Norfloxacin blocks DNA replication by interfering with an ATP-induced structural transition of DNA complexed with DNA gyrase (topoisomerase).
Mode of action: inhibits bacterial DNA replication
Antimicrobial spectrum: Gram-negative bacteria; less effective against Gram-positive bacteria

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

1471517

1471550

1471583

1471619

BP670

Norfloxacin, British Pharmacopoeia (BP) Reference Standard

PHR2233

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H319

Precautionary Statements

P264 - P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

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Norfloxacin, a fluoroquinolone antibacterial agent. Classification, mechanism of action, and in vitro activity.

E J Goldstein

The American journal of medicine, 82(6B), 3-17 (1987-06-26)

Norfloxacin is an orally absorbed fluoroquinolone antibacterial with a fluorine at position 6 and a piperazine ring at position 7. These changes have resulted in a marked enhancement (compared with that of the older quinolones) of in vitro antibacterial activity.

Bacterial resistance to norfloxacin and other newer quinolones: pattern and prospects.

D R Nalin

European journal of cancer & clinical oncology, 24 Suppl 1, S55-S61 (1988-01-01)

Ciprofloxacin and norfloxacin, two fluoroquinolone antimicrobials.

D E Nix et al.

Clinical pharmacy, 6(2), 105-117 (1987-02-01)

The chemistry, mechanism of action, antimicrobial spectrum, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of ciprofloxacin and norfloxacin are reviewed, and mechanisms of antimicrobial resistance and drug and laboratory interactions are described. Norfloxacin is the first antimicrobial in

Review of the bioavailability and pharmacokinetics of oral norfloxacin.

G E Stein

The American journal of medicine, 82(6B), 18-21 (1987-06-26)

The pharmacokinetic profile of norfloxacin, an oral fluoroquinolone, is more complex than that of many antibacterial agents. Following administration of a 400-mg dose, peak serum concentrations of 1.5 to 2.0 micrograms/ml are achieved within one to two hours. The drug

Trend of plasmid-mediated quinolone resistance genes at the Children's Hospital in Tunisia.

Nour El-Houda Jlili et al.

Journal of medical microbiology, 63(Pt 2), 195-202 (2013-11-07)

The prevalence of plasmid-mediated quinolone resistance genes [qnr, aac(6')-Ib-cr and qepA] was sought among Enterobacteriaceae strains obtained from the Children's Hospital of Tunis (Tunisia). Non-duplicate isolates (n = 278) with resistance to extended-spectrum cephalosporins and collected in 2003, 2007, 2008 and 2009

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