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Merck
CN

O0500000

Oxytetracycline hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

5-Hydroxytetracycline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C22H24N2O9 · HCl
CAS Number:
Molecular Weight:
496.89
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3853107
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Product Name

Oxytetracycline hydrochloride, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C22H24N2O9.ClH/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);1H/t12-,13-,14+,17+,21-,22+;/m1./s1

SMILES string

Cl.CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O

InChI key

UBDNTYUBJLXUNN-IFLJXUKPSA-N

grade

pharmaceutical primary standard

API family

oxytetracycline

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

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Application

Oxytetracycline hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Health hazard

signalword

Warning

hcodes

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
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Getu Kahsay et al.
Journal of pharmaceutical and biomedical analysis, 75, 199-206 (2013-01-02)
A simple, robust and fast high-performance liquid chromatographic method is described for the analysis of oxytetracycline and its related impurities. The principal peak and impurities are all baseline separated in 20 min using an Inertsil C₈ (150 mm × 4.6
Miaomiao Liu et al.
Applied microbiology and biotechnology, 97(19), 8805-8812 (2012-11-29)
To investigate how the microbial community in activated sludge responded to high antibiotic levels, a bench-scale aerobic wastewater treatment system was used to treat oxytetracycline (OTC) mother liquor (OTC-ML). Removal efficiency of chemical oxygen demand decreased from 64.9 to 51.0 %
Jette Kjeldgaard et al.
mBio, 3(5), e00190-e00112 (2012-08-30)
Fermented sausages, although presumed safe for consumption, sometimes cause serious bacterial infections in humans that may be deadly. Not much is known about why and when this is the case. We tested the hypothesis that residual veterinary antibiotics in meat
Guang-Feng Yang et al.
Bioresource technology, 126, 187-192 (2012-10-18)
A batch test was employed to analyze the joint toxicity of copper (II) and oxytetracycline (OTC), OTC and sulfide, phenol and sulfide (S(2-)), phenol and copper (II), and OTC, copper (II) and substrate on an Anammox mixed culture. The joint
A Relun et al.
Animal : an international journal of animal bioscience, 7(9), 1542-1550 (2013-05-02)
This study aimed to catalogue the digital dermatitis (DD) treatment practices used by French dairy farmers and to identify the motivators and barriers to the adoption of these treatments. A semi-structured survey was conducted involving 65 farmers in the main

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