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O1002

Oxacillin sodium salt monohydrate

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About This Item

Linear Formula:
C19H18N3O5SNa · H2O
CAS Number:
7240-38-2
Molecular Weight:
441.43
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
24897869
EC Number:
214-636-3
Beilstein/REAXYS Number:
4287093
MDL number:
MFCD00167146

Key Documents

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InChI key

ZVIYWUUZWWBNMB-VICXVTCVSA-M

InChI

1S/C19H19N3O5S.Na.H2O/c1-9-11(12(21-27-9)10-7-5-4-6-8-10)15(23)20-13-16(24)22-14(18(25)26)19(2,3)28-17(13)22;;/h4-8,13-14,17H,1-3H3,(H,20,23)(H,25,26);;1H2/q;+1;/p-1/t13-,14+,17-;;/m1../s1

SMILES string

[Na+].[H]O[H].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)c3c(C)onc3-c4ccccc4)C([O-])=O

form

powder

solubility

water: 50-52 mg/mL, clear to very slightly hazy, colorless to very faintly yellow

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

2-8°C

Quality Level

200

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Application

Oxacillin sodium salt monohydrate has been used in penicillin (PEN) standards. In turbidimetric method, oxacillin sodium salt monohydrate has been used in the medium with antibiotic.

Biochem/physiol Actions

Oxacillin and its derivatives are released through urine with the help of glomerular filtration and tubular secretion. It can be used in nursing mothers. Oxacillin is used in the treatment of methicillin-susceptible S. aureus (MSSA) infections. It shows resistance to penicillinase.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000138613
0000127722
0000114226
0000114225
0000087414

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Drugs and Lactation Database (LactMed) (2006)
An easy-to-use, rapid and inexpensive method to determine methicillin resistance in Staphylococcus aureus.
Gocmen JS, et al.
Journal of Clinical and Experimental Investigations, 7(3), 225-251 (2016)
The Washington Manual Infectious Diseases Subspecialty Consult, 352-352 (2005)
Nancy Tawil et al.
Biosensors & bioelectronics, 49, 334-340 (2013-06-26)
Two hundred fifty Staphylococcus aureus clinical isolates were studied to determine their susceptibilities to β-lactam antibiotics. Among these isolates, 16 were methicillin-sensitive S. aureus (MSSA), 207 were methicillin-resistant S. aureus (MRSA) and 27 were borderline oxacillin-resistant S. aureus (BORSA). Currently
Galoz Kaneti et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(12), 4834-4843 (2013-08-24)
In previous studies, the oligo-acyl-lysyl (OAK) C12(ω7)K-β12 added to cultures of gram-positive bacteria exerted a bacteriostatic activity that was associated with membrane depolarization, even at high concentrations. Here, we report that multidrug-resistant Staphylococcus aureus strains, unlike other gram-positive species, have
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