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P2428

Proscillaridin A

analytical standard

Synonym(s):

3-(6-Deoxy-α-L-mannopyranosyloxyl)-14-hydroxybufa-4,20,22-trienolide, Scillarenin 3β-rhamnoside

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About This Item

Empirical Formula (Hill Notation):
C30H42O8
CAS Number:
466-06-8
Molecular Weight:
530.65
UNSPSC Code:
41116107
PubChem Substance ID:
329820137
EC Number:
207-370-4
MDL number:
MFCD00214065
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grade

analytical standard

assay

≥80%

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

food and beverages
forensics and toxicology
veterinary

format

neat

storage temp.

2-8°C

SMILES string

C[C@]12CC[C@]3([H])[C@@]4(C)CC[C@H](O[C@]5([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)C=C4CC[C@@]3([H])[C@@]1(O)CC[C@@H]2C6=COC(C=C6)=O

InChI

1S/C30H42O8/c1-16-24(32)25(33)26(34)27(37-16)38-19-8-11-28(2)18(14-19)5-6-22-21(28)9-12-29(3)20(10-13-30(22,29)35)17-4-7-23(31)36-15-17/h4,7,14-16,19-22,24-27,32-35H,5-6,8-13H2,1-3H3/t16-,19?,20?,21?,22?,24-,25+,26+,27-,28?,29?,30?/m0/s1

InChI key

MYEJFUXQJGHEQK-RLQJMXQZSA-N

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General description

Proscillaridin A may be used as a standard in the determination of proscillaridin A in the Scilla bifolia perennial herb extract, using thin layer chromatography (TLC) and high performance liquid chromatography coupled with mass spectrometry (HPLC).

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
SLBH2455V
SLBD7289V
SLBC1892V
011M1908V

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T Tanase et al.
Biological & pharmaceutical bulletin, 16(4), 431-433 (1993-04-01)
Elevation of intracellular sodium ion concentration in human erythrocyte induced by the cardiac glycoside, proscillaridin, and its four derivatives was measured using 23Na NMR spectrometry. In this examination, there was a significant correlation between the time to half maximum inotropic
Katarzyna Winnicka et al.
Biological & pharmaceutical bulletin, 31(6), 1131-1140 (2008-06-04)
Three derivatives of ouabain, digoxin and proscillaridin A containing the carboxylic group instead of the lactone moiety were synthesized and examined for cytotoxicity in human breast cancer cells. Evaluation of the cytotoxicity of these compounds employing an MTT assay and
Hesham R El-Seedi et al.
Journal of ethnopharmacology, 145(3), 746-757 (2012-12-12)
Medicinal plants from the Sinai desert are widely used in traditional Bedouin medicine to treat a range of conditions including, cancers, and may thus be useful sources of novel anti-tumor compounds. Information on plants used in this way was obtained
Katarzyna Winnicka et al.
Natural product research, 24(3), 274-285 (2010-02-09)
In this study, we looked at the effect of ouabain, digoxin and proscillaridin A on human fibroblasts. These data show that low concentrations of ouabain, digoxin and proscillaridin A can activate proliferation of human fibroblasts, suggesting that the Na+, K+-adenosine
Elodie M Da Costa et al.
Journal of experimental & clinical cancer research : CR, 38(1), 251-251 (2019-06-15)
Cardiac glycosides are approved for the treatment of heart failure as Na+/K+ pump inhibitors. Their repurposing in oncology is currently investigated in preclinical and clinical studies. However, the identification of a specific cancer type defined by a molecular signature to
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