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P4347

Sigma-Aldrich

Propylene Glycol

meets USP testing specifications

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Synonym(s):
1,2-Propanediol, 1,2-PDO, Methylethyl glycol, Propane-1,2-diol, Propylene glycol
Linear Formula:
CH3CH(OH)CH2OH
CAS Number:
57-55-6
Molecular Weight:
76.09
Beilstein:
1340498
EC Number:
200-338-0
MDL number:
MFCD00064272
PubChem Substance ID:
24898528
NACRES:
NA.25

Agency

USP/NF
meets USP testing specifications

Quality Level

200

vapor density

2.62 (vs air)

vapor pressure

0.08 mmHg ( 20 °C)

autoignition temp.

779 °F

expl. lim.

12.5 %

refractive index

n20/D 1.432 (lit.)

bp

187 °C (lit.)

mp

−60 °C (lit.)

density

1.036 g/mL at 25 °C (lit.)

application(s)

general analytical
pharmaceutical (small molecule)
sample preparation

SMILES string

CC(O)CO

InChI

1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3

InChI key

DNIAPMSPPWPWGF-UHFFFAOYSA-N

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General description

Propylene glycol, a low-molecular-weight aliphatic alcohol, holds significance as a key solvent in biological and pharmaceutical formulation research. Its outstanding miscibility with water and diverse organic compounds, coupled with its low freezing point, low vapor pressure, and non-toxic nature, positions it as a preferred choice for a variety of research applications, particularly in sensitive biological assays and pharmaceutical preparations.

Going beyond its solvent capabilities, propylene glycol excels as an excipient in pharmaceutical formulations, enhancing the solubility and stability of therapeutic molecules and pharmaceutical additives. This attribute proves indispensable in excipient and drug delivery research, contributing to the development of more efficacious and stable medications. In biochemical and physiological research, propylene glycol functions as a potent cryoprotectant, safeguarding cells and tissues from freezing-induced damage. Its application extends to investigations of drug absorption, metabolism, and distribution, providing researchers with a crucial tool to decipher the intricate journey of drugs within the body.

The versatility of propylene glycol extends to molecular biology, particularly in Polymerase Chain Reaction (PCR), where it safeguards DNA and RNA strands, ensuring reliable and reproducible results. Studies demonstrate its exceptional ability to stabilize DNA for extended periods, making it an essential component for long-term sample preservation in genetic and genomic analyses. In the pharmaceutical industry, propylene glycol finds extensive use as a solvent and extraction medium, playing a pivotal role in drug development research, facilitating efficient extraction and purification of bioactive compounds.

Application

Propylene glycol has been used:
  • for removing excess Oil Red O stain in zebrafish larvae
  • in the preparation of alginate hydrogels
  • for the dissolution of androstenone
  • for the calibration of cone beam scanner in computed tomography

Features and Benefits

  • Versatile and adaptable for a wide variety of laboratory and research applications
  • Meets USP testing specifications

Other Notes

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comparable product

Product No.
Description
Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

219.2 °F - closed cup

Flash Point(C)

104 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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