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Merck
CN

P4554

Proparacaine hydrochloride

analytical standard

Synonym(s):

Proxymetacaine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H26N2O3 · HCl
CAS Number:
5875-06-9
Molecular Weight:
330.85
NACRES:
NA.24
PubChem Substance ID:
329820210
UNSPSC Code:
41116107
EC Number:
227-541-7
MDL number:
MFCD00083467

Key Documents

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Product Name

Proparacaine hydrochloride, analytical standard

InChI key

BFUUJUGQJUTPAF-UHFFFAOYSA-N

InChI

1S/C16H26N2O3.ClH/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H

SMILES string

Cl.CCCOc1ccc(cc1N)C(=O)OCCN(CC)CC

grade

analytical standard

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

200

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Topical ophthalmic anesthetic

General description

Proparacaine hydrochloride is a topical ocular anesthetic, which is commonly used in pediatric patients.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

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Applied Pharmacology for Veterinary Technicians (2009)
X Sun et al.
Acta paediatrica (Oslo, Norway : 1992), 99(3), 329-334 (2009-12-05)
To assess whether non-pharmacological and/or pharmacological measures lead to decreased pain during an eye examination in preterm infants. . Systematic review. Premature infants meeting the criteria for screening eye examination for retinopathy. Databases were searched through the Ovid interface. Randomized
M Mehta et al.
Journal of perinatology : official journal of the California Perinatal Association, 30(11), 731-735 (2010-03-20)
The efficacy of topical anesthesia during retinopathy of prematurity (ROP) screening has been a controversial issue. To determine the efficacy of proparacaine eye drops (0.5%), we compared the Premature Infant Pain Profile (PIPP) scores in 40 preterm infants undergoing ROP
Gregory R Blaha et al.
Retina (Philadelphia, Pa.), 31(3), 535-539 (2010-11-26)
To compare the effectiveness of four different anesthetic methods for intravitreal injection. Twenty-four patients each received four intravitreal injections using each of four types of anesthesia (proparacaine, tetracaine, lidocaine pledget, and subconjunctival injection of lidocaine) in a prospective, masked, randomized
Ditipriya R Mukhopadhyay et al.
Journal of cataract and refractive surgery, 37(5), 907-913 (2011-03-23)
To assess the effect of a combination of proparacaine 0.50%-sodium fluorescein 0.25% and ultrasound (US) pachymetry on central and midperipheral corneal thickness. School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom. Case series. Topographic measurements of corneal
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