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Merck
CN

P4554

Proparacaine hydrochloride

analytical standard

Synonym(s):

Proxymetacaine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H26N2O3 · HCl
CAS Number:
5875-06-9
Molecular Weight:
330.85
NACRES:
NA.24
PubChem Substance ID:
329820210
UNSPSC Code:
41116107
EC Number:
227-541-7
MDL number:
MFCD00083467

Key Documents

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InChI key

BFUUJUGQJUTPAF-UHFFFAOYSA-N

InChI

1S/C16H26N2O3.ClH/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H

SMILES string

Cl.CCCOc1ccc(cc1N)C(=O)OCCN(CC)CC

grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

200

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

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General description

Proparacaine hydrochloride is a topical ocular anesthetic, which is commonly used in pediatric patients.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Topical ophthalmic anesthetic

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

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Pediatric Cataract Surgery: Techniques, Complications, and Management (2005)
Lana Rifkin et al.
Retina (Philadelphia, Pa.), 32(4), 696-700 (2011-11-16)
To determine factors associated with patients' comfort during routine in-office intravitreal injection. Sixty patients receiving intravitreal injections over 15 months for macular edema because of diabetes, age-related macular degeneration, or retinal vein occlusion who were randomized into 3 groups to
Michael J Davis et al.
Retina (Philadelphia, Pa.), 32(4), 701-705 (2012-01-28)
To determine whether there is a difference in anesthetic effect between topical proparacaine drops, 4% lidocaine solution, or 3.5% lidocaine gel, and whether this has an impact on the overall injection experience. One hundred and twenty sequential patients undergoing intravitreal
Takefumi Yamaguchi et al.
Investigative ophthalmology & visual science, 55(11), 7457-7466 (2014-10-18)
We investigated bilateral tear cytokine levels in patients with unilateral bacterial keratitis (BK) as associated with in vivo confocal microscopic (IVCM) alterations in corneal nerves and dendritiform immune cells (DCs). A total of 54 (13 BK, 13 contralateral, 28 healthy
X Sun et al.
Acta paediatrica (Oslo, Norway : 1992), 99(3), 329-334 (2009-12-05)
To assess whether non-pharmacological and/or pharmacological measures lead to decreased pain during an eye examination in preterm infants. . Systematic review. Premature infants meeting the criteria for screening eye examination for retinopathy. Databases were searched through the Ovid interface. Randomized
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